Ingredients and solutions for the food industry
Microorganisms and active ingredients for human health
Lactic acid bacteria for the agri-veterinary sector

Our commitment to sustainability: a review of an evolving journey

We are proud to present the fifth edition of our Sustainability Report, an opportunity to reflect on the milestones achieved and the challenges ahead. In recent years, we have implemented significant projects, particularly in the field of circular economy, transforming our production cycle. Thanks to these initiatives, we have achieved a 70% reduction in waste production, redirecting over 12,000 tons of by-products annually into new production cycles, keeping materials in value chains as long as possible.

On the social front, we have focused on employee growth and stability: over 97% of our contracts are permanent, and nearly 95% of our staff have participated in training activities. This focus has allowed us to face challenging periods like the pandemic with resilience.

For Sacco System, sustainability is a strategic pillar driving research and innovation, aiming to address global challenges such as food waste reduction and the promotion of sustainable agri-food supply chains.

Starting in 2026, we will comply with the EU’s Corporate Sustainability Reporting Directive (CSRD), a crucial step in consolidating our approach. We are already working on integrated reporting, involving all group companies and updating materiality topics based on the double materiality principle to ensure a business model aligned with stakeholder expectations and environmental and social challenges.

Sacco System will continue to contribute to sustainable development, adapting to an ever-changing context and ensuring a resilient model through dialogue and engagement with all our partners.

Latest News

19 March 2026
A regulatory achievement for Sacco System: our Heat-Inactivated CRL1505® receives GRAS status

An important regulatory goal has been achieved with the conclusion reached by an independent expert panel for the self-affirmed GRAS (Generally Recognized as Safe) determination of our postbiotic CRL1505® HI.

24 January 2026
SYNBIO®: Sacco System’s probiotic support for healthy ageing

The global population is ageing faster than ever before. In 2019, life expectancy at birth reached 72.8 years almost 9 years more than in 1990. In this context, staying healthy

22 December 2025
Sacco System grows in Latin America: BioInsumos in Uruguay and Sacco Brasil acquired.

The Group is accelerating its South American growth strategy through a twofold transaction: the acquisition of a Uruguayan company and the full absorption of its Brazilian subsidiary. The Group is

11 December 2025
Sacco System Presents PerforMilk®: Unlocking Milk’s Full Potential by Preserving Protein Quality 

Milk is the most precious resource in dairy production. High-quality dairy products start with high-quality milk—and in today’s rapidly evolving dairy landscape, protecting that quality has never been more critical. 

20 November 2025
Unveiling the survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model

“Survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model” is the title of the study that has been

07 February 2025
L. rhamnosus CA15 Achieves GRAS Status: A Milestone for Women’s Health

GRAS (Generally Recognised as Safe) is a designation by the US Food and Drug Administration (FDA) that indicates that a substance is considered safe based on expert consensus or a

08 January 2025
Sacco System Australia’s Heat-Inactivated Postbiotics Receive Positive Recommendations from FSANZ

Brisbane, 8 January 2025 Sacco System Australia, a leader in innovative probiotic and postbiotic solutions, is proud to announce that L. rhamnosus CRL 1505 HI (heat-inactivated) and Lactobacillus acidophilus LA1

25 November 2024
News
Our 2023 sustainability report is online!

We are proud to present the fifth edition of our Sustainability Report, an opportunity to reflect on the milestones achieved and the challenges ahead…

16 April 2024
News
Sacco System is pleased to announce the grand opening of its development site in Australia.

Today in the presence of Luna Angelini Marinucci, from 2022 the Consul of Italy in Brisbane, with territorial jurisdiction over the State of Queensland…

26 March 2024
News
Sacco System companies have been awarded as Sustainability champions by Ecovadis

At Sacco System we have always put Sustainability at the very core of our activities and our commitment, which is why we are proud that our companies Caglificio Clerici…

18 March 2024
News
List Biotherapeutics and Sacco System Announce Lead Share Agreement

List Biotherapeutics, Inc. (List Bio) and Sacco System Australia Pty Ltd (Sacco) today announced a lead share agreement…

26 February 2024
News
CSL FRANCE becomes SACCO SYSTEM FRANCE

Sacco System is the international biotechnological company dedicated to the food, nutraceutical, and pharmaceutical industries…

Today in the presence of Luna Angelini Marinucci, from 2022 the Consul of Italy in Brisbane, with territorial jurisdiction over the State of Queensland and over the Northern Territory the ribbon has been cut on the new Sacco System development site in Brisbane – Australia. Sacco System is a company with strong values, born over 150 years ago and still owned by the Verga Family, starting with the rennet production, nowadays is recognized worldwide as a biotech excellence in the production if enzyme, cultures, probiotics, postbiotics and LPB’s.

Our Brisbane laboratories are designed to deliver early development for our fermentations. We aim to create industrial processes that are robust, reliable and compliant to regulation for a broad variety of microbes. Starting with our in-silico work we can bring all steps of fermentations to a volume of 30L to deliver the information necessary for our larger scale facilities to work effectively ”, said Max Rossetto, Microbial Therapeutics Global Business Development Director.

Being in Australia opening our development site for Next-gen microorganisms and live biotherapeutics is sensational and absolutely and totally inspirational per se. And working hard to make it became an excellence for Sacco System Group and for the Australian State is what we should be inspired to do in the next years! ” said Viola Verga during her speech during the Grand Opening.

Australia was chosen as the site of our process development related to Next-gen microorganisms and live biotherapeutics for a number of reasons. It is easy set up a business in Australia, a modern, high quality business location with stable government, transparent regulations and which has deep and broad connections with Italy as mentioned by the Consul. This together with the presence of a cluster of microbiome related businesses and an impressive academic sector in Southern Queensland made Brisbane a natural choice for the first Sacco System site in the Asia Pacific region.

Latest News

19 March 2026
A regulatory achievement for Sacco System: our Heat-Inactivated CRL1505® receives GRAS status

An important regulatory goal has been achieved with the conclusion reached by an independent expert panel for the self-affirmed GRAS (Generally Recognized as Safe) determination of our postbiotic CRL1505® HI.

24 January 2026
SYNBIO®: Sacco System’s probiotic support for healthy ageing

The global population is ageing faster than ever before. In 2019, life expectancy at birth reached 72.8 years almost 9 years more than in 1990. In this context, staying healthy

22 December 2025
Sacco System grows in Latin America: BioInsumos in Uruguay and Sacco Brasil acquired.

The Group is accelerating its South American growth strategy through a twofold transaction: the acquisition of a Uruguayan company and the full absorption of its Brazilian subsidiary. The Group is

11 December 2025
Sacco System Presents PerforMilk®: Unlocking Milk’s Full Potential by Preserving Protein Quality 

Milk is the most precious resource in dairy production. High-quality dairy products start with high-quality milk—and in today’s rapidly evolving dairy landscape, protecting that quality has never been more critical. 

20 November 2025
Unveiling the survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model

“Survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model” is the title of the study that has been

07 February 2025
L. rhamnosus CA15 Achieves GRAS Status: A Milestone for Women’s Health

GRAS (Generally Recognised as Safe) is a designation by the US Food and Drug Administration (FDA) that indicates that a substance is considered safe based on expert consensus or a

08 January 2025
Sacco System Australia’s Heat-Inactivated Postbiotics Receive Positive Recommendations from FSANZ

Brisbane, 8 January 2025 Sacco System Australia, a leader in innovative probiotic and postbiotic solutions, is proud to announce that L. rhamnosus CRL 1505 HI (heat-inactivated) and Lactobacillus acidophilus LA1

25 November 2024
News
Our 2023 sustainability report is online!

We are proud to present the fifth edition of our Sustainability Report, an opportunity to reflect on the milestones achieved and the challenges ahead…

16 April 2024
News
Sacco System is pleased to announce the grand opening of its development site in Australia.

Today in the presence of Luna Angelini Marinucci, from 2022 the Consul of Italy in Brisbane, with territorial jurisdiction over the State of Queensland…

26 March 2024
News
Sacco System companies have been awarded as Sustainability champions by Ecovadis

At Sacco System we have always put Sustainability at the very core of our activities and our commitment, which is why we are proud that our companies Caglificio Clerici…

18 March 2024
News
List Biotherapeutics and Sacco System Announce Lead Share Agreement

List Biotherapeutics, Inc. (List Bio) and Sacco System Australia Pty Ltd (Sacco) today announced a lead share agreement…

26 February 2024
News
CSL FRANCE becomes SACCO SYSTEM FRANCE

Sacco System is the international biotechnological company dedicated to the food, nutraceutical, and pharmaceutical industries…

At Sacco System we have always put Sustainability at the very core of our activities and our commitment, which is why we are proud that our companies Caglificio Clerici, Sacco and Centro Sperimentale del Latte have been awarded sustainability champions by Ecovadis.

With a global network of more than 130,000 companies evaluated, Ecovadis is today the world’s largest and most trusted provider of corporate sustainability assessments, and its awards are given to the best 35 percent of companies evaluated by EcoVadis.

To be eligible for a medal, a company must achieve a minimum score of 30 in each of four areas:

  • Environment
  • Ethics
  • Labor Practices and Human Rights
  • Sustainable Purchasing

This year Sacco Sacco System companies distinguished themselves in two categories:
“Manufacture of dairy products” in which Caglificio Clerici scored 75 out of 100 points.
“Manufacture of other chemical products n.e.c.” in which Sacco and Centro Sperimentale del Latte respectively scored 61 and 60 points out of 100.

Latest News

19 March 2026
A regulatory achievement for Sacco System: our Heat-Inactivated CRL1505® receives GRAS status

An important regulatory goal has been achieved with the conclusion reached by an independent expert panel for the self-affirmed GRAS (Generally Recognized as Safe) determination of our postbiotic CRL1505® HI.

24 January 2026
SYNBIO®: Sacco System’s probiotic support for healthy ageing

The global population is ageing faster than ever before. In 2019, life expectancy at birth reached 72.8 years almost 9 years more than in 1990. In this context, staying healthy

22 December 2025
Sacco System grows in Latin America: BioInsumos in Uruguay and Sacco Brasil acquired.

The Group is accelerating its South American growth strategy through a twofold transaction: the acquisition of a Uruguayan company and the full absorption of its Brazilian subsidiary. The Group is

11 December 2025
Sacco System Presents PerforMilk®: Unlocking Milk’s Full Potential by Preserving Protein Quality 

Milk is the most precious resource in dairy production. High-quality dairy products start with high-quality milk—and in today’s rapidly evolving dairy landscape, protecting that quality has never been more critical. 

20 November 2025
Unveiling the survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model

“Survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model” is the title of the study that has been

07 February 2025
L. rhamnosus CA15 Achieves GRAS Status: A Milestone for Women’s Health

GRAS (Generally Recognised as Safe) is a designation by the US Food and Drug Administration (FDA) that indicates that a substance is considered safe based on expert consensus or a

08 January 2025
Sacco System Australia’s Heat-Inactivated Postbiotics Receive Positive Recommendations from FSANZ

Brisbane, 8 January 2025 Sacco System Australia, a leader in innovative probiotic and postbiotic solutions, is proud to announce that L. rhamnosus CRL 1505 HI (heat-inactivated) and Lactobacillus acidophilus LA1

25 November 2024
News
Our 2023 sustainability report is online!

We are proud to present the fifth edition of our Sustainability Report, an opportunity to reflect on the milestones achieved and the challenges ahead…

16 April 2024
News
Sacco System is pleased to announce the grand opening of its development site in Australia.

Today in the presence of Luna Angelini Marinucci, from 2022 the Consul of Italy in Brisbane, with territorial jurisdiction over the State of Queensland…

26 March 2024
News
Sacco System companies have been awarded as Sustainability champions by Ecovadis

At Sacco System we have always put Sustainability at the very core of our activities and our commitment, which is why we are proud that our companies Caglificio Clerici…

18 March 2024
News
List Biotherapeutics and Sacco System Announce Lead Share Agreement

List Biotherapeutics, Inc. (List Bio) and Sacco System Australia Pty Ltd (Sacco) today announced a lead share agreement…

26 February 2024
News
CSL FRANCE becomes SACCO SYSTEM FRANCE

Sacco System is the international biotechnological company dedicated to the food, nutraceutical, and pharmaceutical industries…

Indianapolis, Ind., and Yeerongpilly, Queensland, Australia, March 13, 2024 – List Biotherapeutics, Inc. (List Bio) and Sacco System Australia Pty Ltd (Sacco) today announced a lead share agreement to introduce and mutually recommend each other’s microbial development and manufacturing services to prospective customers if one party discovers a project that is better suited to the other party’s capability or capacity. No intellectual property will be exchanged between the companies.

Sacco specializes in the development and production of probiotics, postbiotics and live bacterial therapeutics for the agri-food, food supplements and pharmaceutical industry.

List Bio and its sister company, List Labs, specialize in the development and production of innovative bacterial based therapeutic products, including GMP Manufacturing of live biotherapeutic products (LBPs), and other types of microbiome-based therapeutics. Expertise includes vast experience in purification of bacterially derived proteins and toxins for the pharmaceutical and biotechnology industries, with a catalog of over 100 reagent grade products used in medical research and vaccine development throughout the world. List Labs boasts over 45 years of experience with bacterial derived products and a facility in Campbell, Calif. for manufacturing of early phase clinical trial material.    

“This lead share agreement will help us meet the diverse global needs of microbiome therapeutics development and commercialization in a thriving market, where over 100 companies are actively developing more than 240 microbiome modulator candidates,” said List Bio President and CEO Jonathan Jo. “We are delighted to expand List Labs and List Bio’s integrated cGMP pharma grade anaerobic and spore forming microbe production capabilities to biotherapeutic developers in Europe and the Asia Pacific region through Sacco’s strong client base.”

Sacco Managing Director John Goebel said, “Sacco looks forward to offering our large-scale fermentation capabilities to any List Bio or List Labs biotherapeutics clients who wish to manufacture probiotics and LBPs in large volume. We are confident that this will be the first of many future strategic alliances as the microbiome market continues to grow.” 

About Sacco System

Sacco System is an international company with a deep expertise in research and production of bacteria for food, plant, animal nutrition, nutraceutical, and pharmaceutical industries, built on more than 150 years of tradition, know-how and innovation.

Heritage in Lactic Acid Bacteria (LAB) began in 1948, when Dr Leo Vesely founded Centro Sperimentale del Latte (CSL, integral part of Sacco System group) to improve maternal health and children’s nutrition.
Operating today in over 110 countries worldwide, Sacco System provides its expertise on probiotic research, development and manufacturing for the human wellbeing. A know-how not limited to LAB but to the entire microbiome landscape.

At Sacco System, expertise lies in tailoring solutions to meet diverse industry needs. Serving as a reliable partner, comprehensive support is available with a range of services and solutions, including:
• Process development & fermentation
• Product formulation
• In vitro and in vivo trials
• Market Expansion
• Regulatory Support
• Molecular biology & laboratory analysis

With its 8 facilities, Sacco System partners with companies in the development, process validation, and finished product manufacturing of probiotics, postbiotics, Next-Generation bacteria (strict anaerobes) and biotherapeutics (LBPs).

max.rossetto@saccosystem.com
Max Rossetto
Global Business  Development Director, Microbial Therapeutics Sacco System

About List Bio

List Biotherapeutics, Inc. is dedicated to meeting the needs of companies seeking to rapidly and cost-effectively advance live biotherapeutic products (LBPs) through Phase 3 clinical development and commercial manufacturing. Incorporated in October 2021 under its parent company, South Korea-based Genome & Company (KOSDAQ: 314130), List Bio complements the clinical Phase 1 and 2 production capabilities of its sister company, List Labs. Together the companies provide an end-to-end manufacturing solution for LBPs. List Bio plans to expand with additional modalities and custom manufacturing at its site in Fishers, IN, with the buildout capacity to become a top 3 global microbiome CDMO. The company’s long-term plan includes a world-class 130,000 sq ft CMO facility that is cGMP compliant with FDA and EMA standards, and that is designed to meet the demands of large-scale manufacturing of aerobic and anaerobic bacterial strains.

For more information, please visit our website http://www.listlabs.com or contact Gary Henderson, Director of Business Development at ghenderson@listlabs.com.

Ultime news

19 March 2026
A regulatory achievement for Sacco System: our Heat-Inactivated CRL1505® receives GRAS status

An important regulatory goal has been achieved with the conclusion reached by an independent expert panel for the self-affirmed GRAS (Generally Recognized as Safe) determination of our postbiotic CRL1505® HI.

24 January 2026
SYNBIO®: Sacco System’s probiotic support for healthy ageing

The global population is ageing faster than ever before. In 2019, life expectancy at birth reached 72.8 years almost 9 years more than in 1990. In this context, staying healthy

22 December 2025
Sacco System grows in Latin America: BioInsumos in Uruguay and Sacco Brasil acquired.

The Group is accelerating its South American growth strategy through a twofold transaction: the acquisition of a Uruguayan company and the full absorption of its Brazilian subsidiary. The Group is

11 December 2025
Sacco System Presents PerforMilk®: Unlocking Milk’s Full Potential by Preserving Protein Quality 

Milk is the most precious resource in dairy production. High-quality dairy products start with high-quality milk—and in today’s rapidly evolving dairy landscape, protecting that quality has never been more critical. 

20 November 2025
Unveiling the survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model

“Survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model” is the title of the study that has been

07 February 2025
L. rhamnosus CA15 Achieves GRAS Status: A Milestone for Women’s Health

GRAS (Generally Recognised as Safe) is a designation by the US Food and Drug Administration (FDA) that indicates that a substance is considered safe based on expert consensus or a

08 January 2025
Sacco System Australia’s Heat-Inactivated Postbiotics Receive Positive Recommendations from FSANZ

Brisbane, 8 January 2025 Sacco System Australia, a leader in innovative probiotic and postbiotic solutions, is proud to announce that L. rhamnosus CRL 1505 HI (heat-inactivated) and Lactobacillus acidophilus LA1

25 November 2024
News
Our 2023 sustainability report is online!

We are proud to present the fifth edition of our Sustainability Report, an opportunity to reflect on the milestones achieved and the challenges ahead…

16 April 2024
News
Sacco System is pleased to announce the grand opening of its development site in Australia.

Today in the presence of Luna Angelini Marinucci, from 2022 the Consul of Italy in Brisbane, with territorial jurisdiction over the State of Queensland…

26 March 2024
News
Sacco System companies have been awarded as Sustainability champions by Ecovadis

At Sacco System we have always put Sustainability at the very core of our activities and our commitment, which is why we are proud that our companies Caglificio Clerici…

18 March 2024
News
List Biotherapeutics and Sacco System Announce Lead Share Agreement

List Biotherapeutics, Inc. (List Bio) and Sacco System Australia Pty Ltd (Sacco) today announced a lead share agreement…

26 February 2024
News
CSL FRANCE becomes SACCO SYSTEM FRANCE

Sacco System is the international biotechnological company dedicated to the food, nutraceutical, and pharmaceutical industries…

Sacco System is the international biotechnological company dedicated to the food, nutraceutical, and pharmaceutical industries, based on tradition, expertise, research, and innovation which sells and distributes its ingredients in more than 110 countries around the world. Today Sacco System is a worldwide company, that maintains a family spirit where people and human relations are at the center. Collaborators, suppliers, and clients are part of a large family based on care and respect.

Sacco System wants to contribute to improving the well-being of humans, animals and plants, as as evidenced by the corporate mission: “Supporting food culture and life”.
The high quality of the products, the continuous and constant innovation process, the capacity to work on the sides of clients, knowledge sharing, the training of employees and an attention for the environment, are the pillars of the organization Sacco System.


Sacco System comprises more than 460 collaborators and a turnover of more than 150 million euros (2022). The production facilities are in Cadorago (Italy), Zelo Buon Persico (Italy), Skurup (Sweden) and Franksville (Wisconsin); there are branches in Singapore, France, Japan and a pilot site dedicated to biotherapeutics in Australia.

CSL FRANCE, founded in 1994, is the French branch of SACCO SYSTEM and has now changed its name to SACCO SYSTEM FRANCE. No changes will occur in the quality of the service and the products offered by SACCO SYSTEM FRANCE, which has been present for more than 30 years on the French market, in Benelux, and in French Africa. It offers a comprehensive portfolio of frozen and lyophilized cultures for acidification, aromatization, refinement, bio-protection, surface treatment, gasogenesis, coagulants, enzymes, and probiotics. The company is committed to providing a high level of technical assistance service and achieving commercial excellence dedicated to its clients.

“I am extremely proud of the journey started in 1994 by CSL France, which saw a name change to become Sacco System France, today, as in the past, always standing alongside French dairies, offering the best biotechnological solutions and technical consultancy services. Sacco System France is now an essential part of the Sacco System group; over time, the Company has grown thanks to the commitment and competence of the People who have worked and collaborated at CSL France. Looking ahead, I see numerous new opportunities, also arising from the markets of African countries. By persistently focusing on excellence in technical assistance and customer orientation, market results will only improve day by day. Sincere thanks go to People who contributed to this success story” (Martino Verga – Ownership).


“The transition from CSL France to SACCO SYSTEM FRANCE is a significant moment, confirming our commitment to further enhance the tradition and unique characteristics of the leading dairy sector in France in a more modern and innovative manner” (Adrian Gauna – Sacco System Regional Sales Director).

Latest News

19 March 2026
A regulatory achievement for Sacco System: our Heat-Inactivated CRL1505® receives GRAS status

An important regulatory goal has been achieved with the conclusion reached by an independent expert panel for the self-affirmed GRAS (Generally Recognized as Safe) determination of our postbiotic CRL1505® HI.

24 January 2026
SYNBIO®: Sacco System’s probiotic support for healthy ageing

The global population is ageing faster than ever before. In 2019, life expectancy at birth reached 72.8 years almost 9 years more than in 1990. In this context, staying healthy

22 December 2025
Sacco System grows in Latin America: BioInsumos in Uruguay and Sacco Brasil acquired.

The Group is accelerating its South American growth strategy through a twofold transaction: the acquisition of a Uruguayan company and the full absorption of its Brazilian subsidiary. The Group is

11 December 2025
Sacco System Presents PerforMilk®: Unlocking Milk’s Full Potential by Preserving Protein Quality 

Milk is the most precious resource in dairy production. High-quality dairy products start with high-quality milk—and in today’s rapidly evolving dairy landscape, protecting that quality has never been more critical. 

20 November 2025
Unveiling the survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model

“Survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model” is the title of the study that has been

07 February 2025
L. rhamnosus CA15 Achieves GRAS Status: A Milestone for Women’s Health

GRAS (Generally Recognised as Safe) is a designation by the US Food and Drug Administration (FDA) that indicates that a substance is considered safe based on expert consensus or a

08 January 2025
Sacco System Australia’s Heat-Inactivated Postbiotics Receive Positive Recommendations from FSANZ

Brisbane, 8 January 2025 Sacco System Australia, a leader in innovative probiotic and postbiotic solutions, is proud to announce that L. rhamnosus CRL 1505 HI (heat-inactivated) and Lactobacillus acidophilus LA1

25 November 2024
News
Our 2023 sustainability report is online!

We are proud to present the fifth edition of our Sustainability Report, an opportunity to reflect on the milestones achieved and the challenges ahead…

16 April 2024
News
Sacco System is pleased to announce the grand opening of its development site in Australia.

Today in the presence of Luna Angelini Marinucci, from 2022 the Consul of Italy in Brisbane, with territorial jurisdiction over the State of Queensland…

26 March 2024
News
Sacco System companies have been awarded as Sustainability champions by Ecovadis

At Sacco System we have always put Sustainability at the very core of our activities and our commitment, which is why we are proud that our companies Caglificio Clerici…

18 March 2024
News
List Biotherapeutics and Sacco System Announce Lead Share Agreement

List Biotherapeutics, Inc. (List Bio) and Sacco System Australia Pty Ltd (Sacco) today announced a lead share agreement…

26 February 2024
News
CSL FRANCE becomes SACCO SYSTEM FRANCE

Sacco System is the international biotechnological company dedicated to the food, nutraceutical, and pharmaceutical industries…

We are proud to announce that Sacco System has made a significant donation in support of Action4Diabetes (A4D), mission—a UK-based charity committed to ensuring free access to crucial medical supplies, healthcare services, and ongoing education for disadvantaged young people living with Type 1 Diabetes in Southeast Asia.

This disease can be life-threatening if not properly treated, and unfortunately, many children in the region suffer due to limited access to basic healthcare. A4D is tirelessly working to change this reality. Viola Verga, board member of Sacco System, recently visited A4D in Vietnam and Laos.

Thank you, Action4Diabetes (A4D), for your commendable mission. Your commitment to making a positive impact on empowering young people with Type 1 Diabetes is an inspiration to us all.

We are extremely pleased to have contributed and supported your valuable daily work.

Latest News

19 March 2026
A regulatory achievement for Sacco System: our Heat-Inactivated CRL1505® receives GRAS status

An important regulatory goal has been achieved with the conclusion reached by an independent expert panel for the self-affirmed GRAS (Generally Recognized as Safe) determination of our postbiotic CRL1505® HI.

24 January 2026
SYNBIO®: Sacco System’s probiotic support for healthy ageing

The global population is ageing faster than ever before. In 2019, life expectancy at birth reached 72.8 years almost 9 years more than in 1990. In this context, staying healthy

22 December 2025
Sacco System grows in Latin America: BioInsumos in Uruguay and Sacco Brasil acquired.

The Group is accelerating its South American growth strategy through a twofold transaction: the acquisition of a Uruguayan company and the full absorption of its Brazilian subsidiary. The Group is

11 December 2025
Sacco System Presents PerforMilk®: Unlocking Milk’s Full Potential by Preserving Protein Quality 

Milk is the most precious resource in dairy production. High-quality dairy products start with high-quality milk—and in today’s rapidly evolving dairy landscape, protecting that quality has never been more critical. 

20 November 2025
Unveiling the survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model

“Survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model” is the title of the study that has been

07 February 2025
L. rhamnosus CA15 Achieves GRAS Status: A Milestone for Women’s Health

GRAS (Generally Recognised as Safe) is a designation by the US Food and Drug Administration (FDA) that indicates that a substance is considered safe based on expert consensus or a

08 January 2025
Sacco System Australia’s Heat-Inactivated Postbiotics Receive Positive Recommendations from FSANZ

Brisbane, 8 January 2025 Sacco System Australia, a leader in innovative probiotic and postbiotic solutions, is proud to announce that L. rhamnosus CRL 1505 HI (heat-inactivated) and Lactobacillus acidophilus LA1

25 November 2024
News
Our 2023 sustainability report is online!

We are proud to present the fifth edition of our Sustainability Report, an opportunity to reflect on the milestones achieved and the challenges ahead…

16 April 2024
News
Sacco System is pleased to announce the grand opening of its development site in Australia.

Today in the presence of Luna Angelini Marinucci, from 2022 the Consul of Italy in Brisbane, with territorial jurisdiction over the State of Queensland…

26 March 2024
News
Sacco System companies have been awarded as Sustainability champions by Ecovadis

At Sacco System we have always put Sustainability at the very core of our activities and our commitment, which is why we are proud that our companies Caglificio Clerici…

18 March 2024
News
List Biotherapeutics and Sacco System Announce Lead Share Agreement

List Biotherapeutics, Inc. (List Bio) and Sacco System Australia Pty Ltd (Sacco) today announced a lead share agreement…

26 February 2024
News
CSL FRANCE becomes SACCO SYSTEM FRANCE

Sacco System is the international biotechnological company dedicated to the food, nutraceutical, and pharmaceutical industries…

This year too, SACCO SYSTEM proudly participates in the Deploy Your Talents (DYT) project, promoted by the Fondazione Sodalitas, with the patronage of the Municipality of Milan and in collaboration with Volunteers for Social.

Deploy Your Talents has reached its 11th edition but is more relevant than ever. The study of STEM subjects proves to be a winning card for entering the workforce more quickly, and there is still much ground to cover in terms of gender diversity.

Sacco System places a strong emphasis on graduates in STEM subjects who find their best placement not only in laboratories but also in production and various departments.

The percentage of women with STEM degrees at Sacco System is 42% of the total STEM graduates.

This new adventure involves the students of the III GA LSA Applied Sciences High School – Claudio Cavalleri in Parabiago. The goal is clear: to guide these students through a journey that ranges from the meaning of a future without stereotypes to emphasizing the crucial value of STEM subjects.

Latest News

19 March 2026
A regulatory achievement for Sacco System: our Heat-Inactivated CRL1505® receives GRAS status

An important regulatory goal has been achieved with the conclusion reached by an independent expert panel for the self-affirmed GRAS (Generally Recognized as Safe) determination of our postbiotic CRL1505® HI.

24 January 2026
SYNBIO®: Sacco System’s probiotic support for healthy ageing

The global population is ageing faster than ever before. In 2019, life expectancy at birth reached 72.8 years almost 9 years more than in 1990. In this context, staying healthy

22 December 2025
Sacco System grows in Latin America: BioInsumos in Uruguay and Sacco Brasil acquired.

The Group is accelerating its South American growth strategy through a twofold transaction: the acquisition of a Uruguayan company and the full absorption of its Brazilian subsidiary. The Group is

11 December 2025
Sacco System Presents PerforMilk®: Unlocking Milk’s Full Potential by Preserving Protein Quality 

Milk is the most precious resource in dairy production. High-quality dairy products start with high-quality milk—and in today’s rapidly evolving dairy landscape, protecting that quality has never been more critical. 

20 November 2025
Unveiling the survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model

“Survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model” is the title of the study that has been

07 February 2025
L. rhamnosus CA15 Achieves GRAS Status: A Milestone for Women’s Health

GRAS (Generally Recognised as Safe) is a designation by the US Food and Drug Administration (FDA) that indicates that a substance is considered safe based on expert consensus or a

08 January 2025
Sacco System Australia’s Heat-Inactivated Postbiotics Receive Positive Recommendations from FSANZ

Brisbane, 8 January 2025 Sacco System Australia, a leader in innovative probiotic and postbiotic solutions, is proud to announce that L. rhamnosus CRL 1505 HI (heat-inactivated) and Lactobacillus acidophilus LA1

25 November 2024
News
Our 2023 sustainability report is online!

We are proud to present the fifth edition of our Sustainability Report, an opportunity to reflect on the milestones achieved and the challenges ahead…

16 April 2024
News
Sacco System is pleased to announce the grand opening of its development site in Australia.

Today in the presence of Luna Angelini Marinucci, from 2022 the Consul of Italy in Brisbane, with territorial jurisdiction over the State of Queensland…

26 March 2024
News
Sacco System companies have been awarded as Sustainability champions by Ecovadis

At Sacco System we have always put Sustainability at the very core of our activities and our commitment, which is why we are proud that our companies Caglificio Clerici…

18 March 2024
News
List Biotherapeutics and Sacco System Announce Lead Share Agreement

List Biotherapeutics, Inc. (List Bio) and Sacco System Australia Pty Ltd (Sacco) today announced a lead share agreement…

26 February 2024
News
CSL FRANCE becomes SACCO SYSTEM FRANCE

Sacco System is the international biotechnological company dedicated to the food, nutraceutical, and pharmaceutical industries…

Sacco System is pleased to announce that the new website ingredients.saccosystem.com is now online.

INgredients is a project launched in 2020 with the aim of making the hidden world of ingredients accessible to everyone. It tells the story of how rennet, lactic ferments, and probiotics are essential ingredients in the most well-known foods and beverages, and their beneficial effects on the well-being of humans, animals, and the environment.

On the new website, you will find various food and non-food products that contain Sacco System’s ingredients, the history of the producing companies, articles, and curiosities from scientific communicators, and the new section “IN viaggio” that will allow you to discover countries, companies, and products from around the world.
In the “INgredients Town” section, the stories and tales of INgredients continue as cartoon characters for the little ones, along with curiosities, games, and videos to better understand the beneficial microorganisms that are essential for the production of yogurt, cheeses, fermented milks, salami, and dietary supplements.

Latest News

19 March 2026
A regulatory achievement for Sacco System: our Heat-Inactivated CRL1505® receives GRAS status

An important regulatory goal has been achieved with the conclusion reached by an independent expert panel for the self-affirmed GRAS (Generally Recognized as Safe) determination of our postbiotic CRL1505® HI.

24 January 2026
SYNBIO®: Sacco System’s probiotic support for healthy ageing

The global population is ageing faster than ever before. In 2019, life expectancy at birth reached 72.8 years almost 9 years more than in 1990. In this context, staying healthy

22 December 2025
Sacco System grows in Latin America: BioInsumos in Uruguay and Sacco Brasil acquired.

The Group is accelerating its South American growth strategy through a twofold transaction: the acquisition of a Uruguayan company and the full absorption of its Brazilian subsidiary. The Group is

11 December 2025
Sacco System Presents PerforMilk®: Unlocking Milk’s Full Potential by Preserving Protein Quality 

Milk is the most precious resource in dairy production. High-quality dairy products start with high-quality milk—and in today’s rapidly evolving dairy landscape, protecting that quality has never been more critical. 

20 November 2025
Unveiling the survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model

“Survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model” is the title of the study that has been

07 February 2025
L. rhamnosus CA15 Achieves GRAS Status: A Milestone for Women’s Health

GRAS (Generally Recognised as Safe) is a designation by the US Food and Drug Administration (FDA) that indicates that a substance is considered safe based on expert consensus or a

08 January 2025
Sacco System Australia’s Heat-Inactivated Postbiotics Receive Positive Recommendations from FSANZ

Brisbane, 8 January 2025 Sacco System Australia, a leader in innovative probiotic and postbiotic solutions, is proud to announce that L. rhamnosus CRL 1505 HI (heat-inactivated) and Lactobacillus acidophilus LA1

25 November 2024
News
Our 2023 sustainability report is online!

We are proud to present the fifth edition of our Sustainability Report, an opportunity to reflect on the milestones achieved and the challenges ahead…

16 April 2024
News
Sacco System is pleased to announce the grand opening of its development site in Australia.

Today in the presence of Luna Angelini Marinucci, from 2022 the Consul of Italy in Brisbane, with territorial jurisdiction over the State of Queensland…

26 March 2024
News
Sacco System companies have been awarded as Sustainability champions by Ecovadis

At Sacco System we have always put Sustainability at the very core of our activities and our commitment, which is why we are proud that our companies Caglificio Clerici…

18 March 2024
News
List Biotherapeutics and Sacco System Announce Lead Share Agreement

List Biotherapeutics, Inc. (List Bio) and Sacco System Australia Pty Ltd (Sacco) today announced a lead share agreement…

26 February 2024
News
CSL FRANCE becomes SACCO SYSTEM FRANCE

Sacco System is the international biotechnological company dedicated to the food, nutraceutical, and pharmaceutical industries…

Join us at the 16th International Scientific Conference on Probiotics, Prebiotics, Gut Microbiota and Health – IPC2023, taking place from June 20-22, 2023, at the Carlton Hotel in beautiful Bratislava, Slovakia

Are you passionate about the fascinating world of gut microbiota and its impact on human health? This is your opportunity to immerse yourself in cutting-edge research, engage with renowned experts, and be part of groundbreaking discussions that shape the future of healthcare!

Our R&D Scientist – Health & Nutrition Business Unit, Valentina Taverniti will be addressing the conference on the 22nd during Gut-Health Axis session with the scientific review “Gut microbiota modulation by probiotics improves inflammaging”.

ABSTRACT:

The health benefits of probiotics are not limited to the gut. Among the many mechanisms on how these systemic health benefits arise, the modulation of the gut microbiota composition through probiotic intake is an important one, as it can impact the metabolic milieu in the gut, and thus regulate specific host cell pathways and responses. In this context, we present a clinical study focused on the use of a well-characterized combination of probiotic strains L. rhamnosus IMC 501® and L. paracasei IMC 502®, named SYNBIO®, that can improve inflammaging and the nutritional status of the elderly.

Latest News

19 March 2026
A regulatory achievement for Sacco System: our Heat-Inactivated CRL1505® receives GRAS status

An important regulatory goal has been achieved with the conclusion reached by an independent expert panel for the self-affirmed GRAS (Generally Recognized as Safe) determination of our postbiotic CRL1505® HI.

24 January 2026
SYNBIO®: Sacco System’s probiotic support for healthy ageing

The global population is ageing faster than ever before. In 2019, life expectancy at birth reached 72.8 years almost 9 years more than in 1990. In this context, staying healthy

22 December 2025
Sacco System grows in Latin America: BioInsumos in Uruguay and Sacco Brasil acquired.

The Group is accelerating its South American growth strategy through a twofold transaction: the acquisition of a Uruguayan company and the full absorption of its Brazilian subsidiary. The Group is

11 December 2025
Sacco System Presents PerforMilk®: Unlocking Milk’s Full Potential by Preserving Protein Quality 

Milk is the most precious resource in dairy production. High-quality dairy products start with high-quality milk—and in today’s rapidly evolving dairy landscape, protecting that quality has never been more critical. 

20 November 2025
Unveiling the survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model

“Survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model” is the title of the study that has been

07 February 2025
L. rhamnosus CA15 Achieves GRAS Status: A Milestone for Women’s Health

GRAS (Generally Recognised as Safe) is a designation by the US Food and Drug Administration (FDA) that indicates that a substance is considered safe based on expert consensus or a

08 January 2025
Sacco System Australia’s Heat-Inactivated Postbiotics Receive Positive Recommendations from FSANZ

Brisbane, 8 January 2025 Sacco System Australia, a leader in innovative probiotic and postbiotic solutions, is proud to announce that L. rhamnosus CRL 1505 HI (heat-inactivated) and Lactobacillus acidophilus LA1

25 November 2024
News
Our 2023 sustainability report is online!

We are proud to present the fifth edition of our Sustainability Report, an opportunity to reflect on the milestones achieved and the challenges ahead…

16 April 2024
News
Sacco System is pleased to announce the grand opening of its development site in Australia.

Today in the presence of Luna Angelini Marinucci, from 2022 the Consul of Italy in Brisbane, with territorial jurisdiction over the State of Queensland…

26 March 2024
News
Sacco System companies have been awarded as Sustainability champions by Ecovadis

At Sacco System we have always put Sustainability at the very core of our activities and our commitment, which is why we are proud that our companies Caglificio Clerici…

18 March 2024
News
List Biotherapeutics and Sacco System Announce Lead Share Agreement

List Biotherapeutics, Inc. (List Bio) and Sacco System Australia Pty Ltd (Sacco) today announced a lead share agreement…

26 February 2024
News
CSL FRANCE becomes SACCO SYSTEM FRANCE

Sacco System is the international biotechnological company dedicated to the food, nutraceutical, and pharmaceutical industries…

SACCO SYSTEM at Vitafoods, May 9-11, in Geneva at Palexpo, Route François-Peyrot 30, 1218 Le Grand-Saconnex, Switzerland.

We look forward to meeting you for three days of inspiration and networking within the microbiome industry.

Visit our booth G260 to connect with our team of experts and hear more about Sacco System’s CultureScience™ and CultureSelect™ portfolio or discover more about our custom fermentation capabilities for probiotics, postbiotcs, next-generation bacteria and live biotherapeutics.

Our services are MADE FOR YOU™

We understand that you might look for a tailor-made solution for the microbiome space, at Sacco System we aim to be your all-in-one partner, we take care of the manufacturing and science, and you can stay focused on your business.

Probiotics, postbiotics, next-generation bacteria and live biotherapeutics, from development to production, we have you covered!


Gut microbiota modulations by probiotics improve inflammaging and metabolic disorders
Wednesday, May 10, 2023 at 3:00 p.m. at the Probiotics Theatre
Speaker: Valentina Taverniti, PhD, Health and Nutrition R&D Scientist at Sacco System

There is increasing evidence of the health benefits of probiotic formulations, both single-strain and multistrain formulations. It is well known that the benefits of orally administered probiotics can extend beyond the gut. Among other mechanisms through which this can take place, the modulation of the gut microbiota composition by probiotics is an important one, as it can result in different metabolites being produced, and thus regulate specific host cell pathways and responses. In this context, we present a clinical study focused on the use of Lactiplantibacillus plantarum IMC 510® on weight management and metabolic improvement of the study participants, and a clinical study of a well-characterized mixture of L. rhamnosus IMC 501® and L. paracasei IMC 502®, named SYNBIO®, that improved inflammaging and the nutritional status in elderly volunteers.

Latest News

19 March 2026
A regulatory achievement for Sacco System: our Heat-Inactivated CRL1505® receives GRAS status

An important regulatory goal has been achieved with the conclusion reached by an independent expert panel for the self-affirmed GRAS (Generally Recognized as Safe) determination of our postbiotic CRL1505® HI.

24 January 2026
SYNBIO®: Sacco System’s probiotic support for healthy ageing

The global population is ageing faster than ever before. In 2019, life expectancy at birth reached 72.8 years almost 9 years more than in 1990. In this context, staying healthy

22 December 2025
Sacco System grows in Latin America: BioInsumos in Uruguay and Sacco Brasil acquired.

The Group is accelerating its South American growth strategy through a twofold transaction: the acquisition of a Uruguayan company and the full absorption of its Brazilian subsidiary. The Group is

11 December 2025
Sacco System Presents PerforMilk®: Unlocking Milk’s Full Potential by Preserving Protein Quality 

Milk is the most precious resource in dairy production. High-quality dairy products start with high-quality milk—and in today’s rapidly evolving dairy landscape, protecting that quality has never been more critical. 

20 November 2025
Unveiling the survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model

“Survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model” is the title of the study that has been

07 February 2025
L. rhamnosus CA15 Achieves GRAS Status: A Milestone for Women’s Health

GRAS (Generally Recognised as Safe) is a designation by the US Food and Drug Administration (FDA) that indicates that a substance is considered safe based on expert consensus or a

08 January 2025
Sacco System Australia’s Heat-Inactivated Postbiotics Receive Positive Recommendations from FSANZ

Brisbane, 8 January 2025 Sacco System Australia, a leader in innovative probiotic and postbiotic solutions, is proud to announce that L. rhamnosus CRL 1505 HI (heat-inactivated) and Lactobacillus acidophilus LA1

25 November 2024
News
Our 2023 sustainability report is online!

We are proud to present the fifth edition of our Sustainability Report, an opportunity to reflect on the milestones achieved and the challenges ahead…

16 April 2024
News
Sacco System is pleased to announce the grand opening of its development site in Australia.

Today in the presence of Luna Angelini Marinucci, from 2022 the Consul of Italy in Brisbane, with territorial jurisdiction over the State of Queensland…

26 March 2024
News
Sacco System companies have been awarded as Sustainability champions by Ecovadis

At Sacco System we have always put Sustainability at the very core of our activities and our commitment, which is why we are proud that our companies Caglificio Clerici…

18 March 2024
News
List Biotherapeutics and Sacco System Announce Lead Share Agreement

List Biotherapeutics, Inc. (List Bio) and Sacco System Australia Pty Ltd (Sacco) today announced a lead share agreement…

26 February 2024
News
CSL FRANCE becomes SACCO SYSTEM FRANCE

Sacco System is the international biotechnological company dedicated to the food, nutraceutical, and pharmaceutical industries…

Once again this year, Sacco Ltd. is among the 1,000 Champions 2023 companies highlighted by the research conducted by the ItalyPost Study Center in collaboration with Corriere della Sera, which have performed best in terms of EBITDA.
Thank you to all those who collaborated to achieve this important milestone.

Latest News

19 March 2026
A regulatory achievement for Sacco System: our Heat-Inactivated CRL1505® receives GRAS status

An important regulatory goal has been achieved with the conclusion reached by an independent expert panel for the self-affirmed GRAS (Generally Recognized as Safe) determination of our postbiotic CRL1505® HI.

24 January 2026
SYNBIO®: Sacco System’s probiotic support for healthy ageing

The global population is ageing faster than ever before. In 2019, life expectancy at birth reached 72.8 years almost 9 years more than in 1990. In this context, staying healthy

22 December 2025
Sacco System grows in Latin America: BioInsumos in Uruguay and Sacco Brasil acquired.

The Group is accelerating its South American growth strategy through a twofold transaction: the acquisition of a Uruguayan company and the full absorption of its Brazilian subsidiary. The Group is

11 December 2025
Sacco System Presents PerforMilk®: Unlocking Milk’s Full Potential by Preserving Protein Quality 

Milk is the most precious resource in dairy production. High-quality dairy products start with high-quality milk—and in today’s rapidly evolving dairy landscape, protecting that quality has never been more critical. 

20 November 2025
Unveiling the survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model

“Survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model” is the title of the study that has been

07 February 2025
L. rhamnosus CA15 Achieves GRAS Status: A Milestone for Women’s Health

GRAS (Generally Recognised as Safe) is a designation by the US Food and Drug Administration (FDA) that indicates that a substance is considered safe based on expert consensus or a

08 January 2025
Sacco System Australia’s Heat-Inactivated Postbiotics Receive Positive Recommendations from FSANZ

Brisbane, 8 January 2025 Sacco System Australia, a leader in innovative probiotic and postbiotic solutions, is proud to announce that L. rhamnosus CRL 1505 HI (heat-inactivated) and Lactobacillus acidophilus LA1

25 November 2024
News
Our 2023 sustainability report is online!

We are proud to present the fifth edition of our Sustainability Report, an opportunity to reflect on the milestones achieved and the challenges ahead…

16 April 2024
News
Sacco System is pleased to announce the grand opening of its development site in Australia.

Today in the presence of Luna Angelini Marinucci, from 2022 the Consul of Italy in Brisbane, with territorial jurisdiction over the State of Queensland…

26 March 2024
News
Sacco System companies have been awarded as Sustainability champions by Ecovadis

At Sacco System we have always put Sustainability at the very core of our activities and our commitment, which is why we are proud that our companies Caglificio Clerici…

18 March 2024
News
List Biotherapeutics and Sacco System Announce Lead Share Agreement

List Biotherapeutics, Inc. (List Bio) and Sacco System Australia Pty Ltd (Sacco) today announced a lead share agreement…

26 February 2024
News
CSL FRANCE becomes SACCO SYSTEM FRANCE

Sacco System is the international biotechnological company dedicated to the food, nutraceutical, and pharmaceutical industries…

On March 3rd we held our Mini Virtual Technical Meeting for Sacco System technologists from the Americas.
We were joined by 35 technologists working in our commercial and technical assistance network for this market, with the participation of representatives from Fermentos del Sur (Chile), BioInsumos (Uruguay), BioInsumos (Bolivia), Chacomer (Paraguay), Provolatte (Venezuela), Raff (Mexico), Tuteur (Argentina), Sacco Brasil, Amerilac (USA), BioVItaLIve (Ecuador), Distribuidora del Caribe (Central America), Abiasa (Mexico), CSL USA (USA), GLI-Linros (Peru), and on this occasion with the great support of Centro Agro Lechero, our distributor for the Colombian market.
The technical meeting on the use of our Lyofast LRB culture in the conservation of milk, presenting a large number of successful cases of application by improving the quality of the raw material and thus improving the quality of dairy products and cheese yield obtained, was an excellent area of enrichment and technical exchange for all attendees.

Latest News

19 March 2026
A regulatory achievement for Sacco System: our Heat-Inactivated CRL1505® receives GRAS status

An important regulatory goal has been achieved with the conclusion reached by an independent expert panel for the self-affirmed GRAS (Generally Recognized as Safe) determination of our postbiotic CRL1505® HI.

24 January 2026
SYNBIO®: Sacco System’s probiotic support for healthy ageing

The global population is ageing faster than ever before. In 2019, life expectancy at birth reached 72.8 years almost 9 years more than in 1990. In this context, staying healthy

22 December 2025
Sacco System grows in Latin America: BioInsumos in Uruguay and Sacco Brasil acquired.

The Group is accelerating its South American growth strategy through a twofold transaction: the acquisition of a Uruguayan company and the full absorption of its Brazilian subsidiary. The Group is

11 December 2025
Sacco System Presents PerforMilk®: Unlocking Milk’s Full Potential by Preserving Protein Quality 

Milk is the most precious resource in dairy production. High-quality dairy products start with high-quality milk—and in today’s rapidly evolving dairy landscape, protecting that quality has never been more critical. 

20 November 2025
Unveiling the survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model

“Survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model” is the title of the study that has been

07 February 2025
L. rhamnosus CA15 Achieves GRAS Status: A Milestone for Women’s Health

GRAS (Generally Recognised as Safe) is a designation by the US Food and Drug Administration (FDA) that indicates that a substance is considered safe based on expert consensus or a

08 January 2025
Sacco System Australia’s Heat-Inactivated Postbiotics Receive Positive Recommendations from FSANZ

Brisbane, 8 January 2025 Sacco System Australia, a leader in innovative probiotic and postbiotic solutions, is proud to announce that L. rhamnosus CRL 1505 HI (heat-inactivated) and Lactobacillus acidophilus LA1

25 November 2024
News
Our 2023 sustainability report is online!

We are proud to present the fifth edition of our Sustainability Report, an opportunity to reflect on the milestones achieved and the challenges ahead…

16 April 2024
News
Sacco System is pleased to announce the grand opening of its development site in Australia.

Today in the presence of Luna Angelini Marinucci, from 2022 the Consul of Italy in Brisbane, with territorial jurisdiction over the State of Queensland…

26 March 2024
News
Sacco System companies have been awarded as Sustainability champions by Ecovadis

At Sacco System we have always put Sustainability at the very core of our activities and our commitment, which is why we are proud that our companies Caglificio Clerici…

18 March 2024
News
List Biotherapeutics and Sacco System Announce Lead Share Agreement

List Biotherapeutics, Inc. (List Bio) and Sacco System Australia Pty Ltd (Sacco) today announced a lead share agreement…

26 February 2024
News
CSL FRANCE becomes SACCO SYSTEM FRANCE

Sacco System is the international biotechnological company dedicated to the food, nutraceutical, and pharmaceutical industries…

Sacco System Launches Microbiome – The complete suite of products and services tailored for the development and scale-up of Probiotics, Postbiotics and Microbial Therapeutics for supplement, biotech and pharma companies.

The FDA defines live biotherapeutics (LBPs) as biological products that contains live organisms and are applied to the prevention, treatment, or cure of a disease or condition. Interest in LBPs as a solution to several health disorders has grown exponentially in the last few years. In full support of this vision, Sacco System is launching Microbiome by Sacco System: its full suite of active ingredients and services conceived for the development and scale-up of Probiotics, Postbiotics and (LBPs)Microbial Therapeutics for application to the supplement, biotech, and pharma industries.

Microbiome blooms in the fertile environment of Sacco System’s proud tradition of continuous innovation and evolution to meet our global customers’ changing needs. The launch of the new Microbiome market area will provide fundamental support to our clients in the development of innovative solutions, while concurrently offering them a substantial sale and marketing edge with respect to their competitors.

“We have been working with Biotherapeutics for many years: CSL Centro Sperimentale del Latte has been among the first producers of probiotics to boast a facility qualified for the manufacturing of microbial pharmaceutical ingredients. Today, we have two production sites hosting a whole range of different processes and fermentations, as well as the downstream capacity ensuing from holding a Drug GMP certification.
With the launch of our new Microbial Therapeutic business-line we are directing our efforts and strong focus to the field of Biotherapeutics. Thanks to the excellent skills and competencies of the people who have joined us, marrying into our existing capabilities, we are fully equipped to offer a complete suite of excellent services to our partners, with a view of bringing next-gen bacteria-based therapeutics to the market” – Marco Caspani, Executive Director of the Microbiome Division of Sacco System.

Sacco System Australia has been recently founded to support our customers’ live biotherapeutics development needs and allows us to take advantage of the outstanding scientific know-how present there.

“We are very proud to be bringing forward a 150-year-old legacy with the expansion of Sacco System’s operating facilities, focusing on Microbial Therapeutics, into the Australian market. This expansion marks an exciting next step for the Live Biotherapeutics industry given the array of opportunities opened by Sacco’s capabilities, from small to large scale Pharma development, its multinational reach and its research capabilities. As CEO for the Sacco System Australia business, the team and I look forward to providing high-quality, tailor-made solutions for the process development, fermentation in the Microbial Therapeutic Bio-Pharma industry.” – John Goebel, CEO of Sacco System Australia.

“Sacco System have decided to leverage their expertise in all aspects of microbiology to enter the Biotherapeutics market. This new investment by Sacco System will provide a unique offering of leading-edge manufacturing and support for companies looking to outsource their biotherapeutics products. Boasting an Australia-based development facility built according to Quality by Design and seamlessly integrated into the fully automated GMP production facilities in Italy, that is supported by state-of-the-art analytics, Sacco System can now bring your project from the bench through to 20,000L batches in GMP. Our team’s expertise, ranging from growing strains -from aerobes to strict anaerobes- to flow cytometry and large-scale manufacturing, is at your disposal to ensure the success of your drug substance development and commercial production.” – Max Rossetto, Global Business Development Director for Microbial Therapeutics of Sacco System.

Sacco System is proudly launching its new Microbiome market area to support companies worldwide in the development, process validation, and commercial production of probiotics, postbiotics, Next-Generation bacteria (from aerobic to obligate anaerobic strains) and live biotherapeutics (LBPs).

Latest News

19 March 2026
A regulatory achievement for Sacco System: our Heat-Inactivated CRL1505® receives GRAS status

An important regulatory goal has been achieved with the conclusion reached by an independent expert panel for the self-affirmed GRAS (Generally Recognized as Safe) determination of our postbiotic CRL1505® HI.

24 January 2026
SYNBIO®: Sacco System’s probiotic support for healthy ageing

The global population is ageing faster than ever before. In 2019, life expectancy at birth reached 72.8 years almost 9 years more than in 1990. In this context, staying healthy

22 December 2025
Sacco System grows in Latin America: BioInsumos in Uruguay and Sacco Brasil acquired.

The Group is accelerating its South American growth strategy through a twofold transaction: the acquisition of a Uruguayan company and the full absorption of its Brazilian subsidiary. The Group is

11 December 2025
Sacco System Presents PerforMilk®: Unlocking Milk’s Full Potential by Preserving Protein Quality 

Milk is the most precious resource in dairy production. High-quality dairy products start with high-quality milk—and in today’s rapidly evolving dairy landscape, protecting that quality has never been more critical. 

20 November 2025
Unveiling the survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model

“Survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model” is the title of the study that has been

07 February 2025
L. rhamnosus CA15 Achieves GRAS Status: A Milestone for Women’s Health

GRAS (Generally Recognised as Safe) is a designation by the US Food and Drug Administration (FDA) that indicates that a substance is considered safe based on expert consensus or a

08 January 2025
Sacco System Australia’s Heat-Inactivated Postbiotics Receive Positive Recommendations from FSANZ

Brisbane, 8 January 2025 Sacco System Australia, a leader in innovative probiotic and postbiotic solutions, is proud to announce that L. rhamnosus CRL 1505 HI (heat-inactivated) and Lactobacillus acidophilus LA1

25 November 2024
News
Our 2023 sustainability report is online!

We are proud to present the fifth edition of our Sustainability Report, an opportunity to reflect on the milestones achieved and the challenges ahead…

16 April 2024
News
Sacco System is pleased to announce the grand opening of its development site in Australia.

Today in the presence of Luna Angelini Marinucci, from 2022 the Consul of Italy in Brisbane, with territorial jurisdiction over the State of Queensland…

26 March 2024
News
Sacco System companies have been awarded as Sustainability champions by Ecovadis

At Sacco System we have always put Sustainability at the very core of our activities and our commitment, which is why we are proud that our companies Caglificio Clerici…

18 March 2024
News
List Biotherapeutics and Sacco System Announce Lead Share Agreement

List Biotherapeutics, Inc. (List Bio) and Sacco System Australia Pty Ltd (Sacco) today announced a lead share agreement…

26 February 2024
News
CSL FRANCE becomes SACCO SYSTEM FRANCE

Sacco System is the international biotechnological company dedicated to the food, nutraceutical, and pharmaceutical industries…

Argentine President Alberto Fernández led, at the Danone plant, the launch of a food produced from a L. rhamnosus CRL 1505™ probiotic strain, developed by CONICET, which improves respiratory and gastrointestinal health.

It is a new line of yogurt that will be distributed in institutions with social purposes throughout the country.

The license for this lactic bacteria, isolated from goat’s milk in Tucumán, is also “exported” – within the framework of an agreement between Conicet and one of the most important probiotic-producing companies in the world, Sacco srl, which allows its commercialization to be included in different foods and biopharmaceuticals.

The L. rhamnosus CRL 1505™ strain is capable of stimulating the immune system, optimizing natural defenses when preventing or dealing with respiratory and intestinal infections caused by viruses and bacteria, thus contributing to an improvement in the quality of life and health.

Attached resources

Latest News

19 March 2026
A regulatory achievement for Sacco System: our Heat-Inactivated CRL1505® receives GRAS status

An important regulatory goal has been achieved with the conclusion reached by an independent expert panel for the self-affirmed GRAS (Generally Recognized as Safe) determination of our postbiotic CRL1505® HI.

24 January 2026
SYNBIO®: Sacco System’s probiotic support for healthy ageing

The global population is ageing faster than ever before. In 2019, life expectancy at birth reached 72.8 years almost 9 years more than in 1990. In this context, staying healthy

22 December 2025
Sacco System grows in Latin America: BioInsumos in Uruguay and Sacco Brasil acquired.

The Group is accelerating its South American growth strategy through a twofold transaction: the acquisition of a Uruguayan company and the full absorption of its Brazilian subsidiary. The Group is

11 December 2025
Sacco System Presents PerforMilk®: Unlocking Milk’s Full Potential by Preserving Protein Quality 

Milk is the most precious resource in dairy production. High-quality dairy products start with high-quality milk—and in today’s rapidly evolving dairy landscape, protecting that quality has never been more critical. 

20 November 2025
Unveiling the survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model

“Survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model” is the title of the study that has been

07 February 2025
L. rhamnosus CA15 Achieves GRAS Status: A Milestone for Women’s Health

GRAS (Generally Recognised as Safe) is a designation by the US Food and Drug Administration (FDA) that indicates that a substance is considered safe based on expert consensus or a

08 January 2025
Sacco System Australia’s Heat-Inactivated Postbiotics Receive Positive Recommendations from FSANZ

Brisbane, 8 January 2025 Sacco System Australia, a leader in innovative probiotic and postbiotic solutions, is proud to announce that L. rhamnosus CRL 1505 HI (heat-inactivated) and Lactobacillus acidophilus LA1

25 November 2024
News
Our 2023 sustainability report is online!

We are proud to present the fifth edition of our Sustainability Report, an opportunity to reflect on the milestones achieved and the challenges ahead…

16 April 2024
News
Sacco System is pleased to announce the grand opening of its development site in Australia.

Today in the presence of Luna Angelini Marinucci, from 2022 the Consul of Italy in Brisbane, with territorial jurisdiction over the State of Queensland…

26 March 2024
News
Sacco System companies have been awarded as Sustainability champions by Ecovadis

At Sacco System we have always put Sustainability at the very core of our activities and our commitment, which is why we are proud that our companies Caglificio Clerici…

18 March 2024
News
List Biotherapeutics and Sacco System Announce Lead Share Agreement

List Biotherapeutics, Inc. (List Bio) and Sacco System Australia Pty Ltd (Sacco) today announced a lead share agreement…

26 February 2024
News
CSL FRANCE becomes SACCO SYSTEM FRANCE

Sacco System is the international biotechnological company dedicated to the food, nutraceutical, and pharmaceutical industries…

Last Saturday we gathered all together to celebrate the 150th anniversary of our first company Caglificio Clerici. A glorious celebration culminating 150 years of family history, passion, tradition and innovation throughout three centuries.
150 years of history, made with passion with all the Sacco System family.
Happy 150th anniversary to CAGLIFICIO CLERICI

Latest News

19 March 2026
A regulatory achievement for Sacco System: our Heat-Inactivated CRL1505® receives GRAS status

An important regulatory goal has been achieved with the conclusion reached by an independent expert panel for the self-affirmed GRAS (Generally Recognized as Safe) determination of our postbiotic CRL1505® HI.

24 January 2026
SYNBIO®: Sacco System’s probiotic support for healthy ageing

The global population is ageing faster than ever before. In 2019, life expectancy at birth reached 72.8 years almost 9 years more than in 1990. In this context, staying healthy

22 December 2025
Sacco System grows in Latin America: BioInsumos in Uruguay and Sacco Brasil acquired.

The Group is accelerating its South American growth strategy through a twofold transaction: the acquisition of a Uruguayan company and the full absorption of its Brazilian subsidiary. The Group is

11 December 2025
Sacco System Presents PerforMilk®: Unlocking Milk’s Full Potential by Preserving Protein Quality 

Milk is the most precious resource in dairy production. High-quality dairy products start with high-quality milk—and in today’s rapidly evolving dairy landscape, protecting that quality has never been more critical. 

20 November 2025
Unveiling the survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model

“Survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model” is the title of the study that has been

07 February 2025
L. rhamnosus CA15 Achieves GRAS Status: A Milestone for Women’s Health

GRAS (Generally Recognised as Safe) is a designation by the US Food and Drug Administration (FDA) that indicates that a substance is considered safe based on expert consensus or a

08 January 2025
Sacco System Australia’s Heat-Inactivated Postbiotics Receive Positive Recommendations from FSANZ

Brisbane, 8 January 2025 Sacco System Australia, a leader in innovative probiotic and postbiotic solutions, is proud to announce that L. rhamnosus CRL 1505 HI (heat-inactivated) and Lactobacillus acidophilus LA1

25 November 2024
News
Our 2023 sustainability report is online!

We are proud to present the fifth edition of our Sustainability Report, an opportunity to reflect on the milestones achieved and the challenges ahead…

16 April 2024
News
Sacco System is pleased to announce the grand opening of its development site in Australia.

Today in the presence of Luna Angelini Marinucci, from 2022 the Consul of Italy in Brisbane, with territorial jurisdiction over the State of Queensland…

26 March 2024
News
Sacco System companies have been awarded as Sustainability champions by Ecovadis

At Sacco System we have always put Sustainability at the very core of our activities and our commitment, which is why we are proud that our companies Caglificio Clerici…

18 March 2024
News
List Biotherapeutics and Sacco System Announce Lead Share Agreement

List Biotherapeutics, Inc. (List Bio) and Sacco System Australia Pty Ltd (Sacco) today announced a lead share agreement…

26 February 2024
News
CSL FRANCE becomes SACCO SYSTEM FRANCE

Sacco System is the international biotechnological company dedicated to the food, nutraceutical, and pharmaceutical industries…

Exclusively distributed in Italy by Metagenics, The Akkermansia Company™ supplement will be available at chemist’s and O.T.C. drugstores in Italy from mid-December onwards. This brand-new supplement contains a strain produced by Sacco System which is being put on sale for the very first time. Clinical trials have shown that this particular strain effectively combats the consequences of a high-fat diet (for instance, increased body fat, the onset of insulin-resistance syndrome and inflammatory states).

The supplement was obtained by isolating (something achieved for the very first time in 2004) the bacterium Akkermansia muciniphila which, according to scientific research, helps to improve the metabolic profile associated with type-2 diabetes and obesity.

In addition to 30 billion pasteurised Akkermansia muciniphila, the supplement also contains chromium for glycaemic control as well as green-tea extract for weight control. A combination of these ingredients has helped to substantiate the EFSA claims.

A close partnership between the Akkermansia Company and Sacco System made it possible to pinpoint a bacterial strain that was unknown until 2004 and place it on the market for the first time. The undoubted challenges of producing this anaerobic organism were only met thanks to the superb teamwork between the two companies. The bacteria are inactivated thanks to a special pasteurisation process which boasts the same levels of effectiveness as the live probiotic.

This innovative product is a huge step ahead in the supplements sector in general, but is particularly seminal in the field of weight-control supplements.

The video at the bottom of the article features Marco Caspani, CEO of the Sacco System company Centro Sperimentale del Latte, who talks us through the Akkermansia Company™ production process.

Akkermansia muciniphila: Significant results in literature

  1. Strain isolated for the first time in 2004 in the human gastrointestinal tract – group led by Professor Willlem M. de Vos, University of Wageningen.

  2. Initial research has shown that large quantities of A. muciniphila in the gastrointestinal tract are inversely related to obesity and type-2 diabetes; the consumption of A. muciniphila does not only improve the metabolic profile of mice (reducing their body fat and insulin-resistance), but also strengthens the gut lining, which in turn lowers levels of endotoxemia and inflammation.

  3. When A. muciniphila is pasteurised, not only does it retain all its health benefits, but its healing power is actually boosted due to the presence of a protein with a heat-stable membrane and immunogenic properties. The Amuc_1100 protein regulates the beneficial action of the bacteria, improving the gut barrier and lowering dyslipidemia as well as reducing insulin-resistance and the accumulation of body fat.

  4. A clinical trial (no. NCT02637115) conducted on 32 overweight/obese and insulin-resistant individuals has shown that oral administration of A. muciniphila(both as a live supplement and a heat-inactivated one) is safe and well tolerated. The pasteurised form of the bacterium led to the improvement of a variety of metabolic parameters, such as insulin sensitivity, overall cholesterol levels and an increase in body fat and weight as well as lowering liver-inflammation markers.

  5. In 2021 the EFSA approved pasteurised A. muciniphila as a novel food with a maximum dosage of 5×1010 cells/day for adults.

Akkermansia muciniphila: Note sul processo produttivo

January 2019

  1. Strain arrives at Sacco and is included in our collection. It was one of the first obligate anaerobes to be included in our collection of strains.

January-December 2019

  1. First small-scale pilot fermentation commenced in January (at Sacco)
  2. First pilot fermentation on a semi-industrial scale (at CSL)

January 2020

  1. Production batch of the pasteurised product for the first time (at Sacco)

April-August 2020

  1. Various tests aimed at optimising the production process (at Sacco)

September 2020

  1. 12000L production batch based on the previous pasteurised product batch (Sacco)

December 2021 – February 2022

  1. Three production batches of 12000L and one production batch of 20000L (at CSL).
    The whole process takes place in an oxygen-deprived environment.

For further information on the Akkermansia Company™ weight-management supplement, on the Akkermansia muciniphila bacterial strain, or just for information about our services, skills and technological know-how as regards the development of traditional and next-generation probiotic strains, and postbiotic formulations, please get in touch with us.

Latest News

19 March 2026
A regulatory achievement for Sacco System: our Heat-Inactivated CRL1505® receives GRAS status

An important regulatory goal has been achieved with the conclusion reached by an independent expert panel for the self-affirmed GRAS (Generally Recognized as Safe) determination of our postbiotic CRL1505® HI.

24 January 2026
SYNBIO®: Sacco System’s probiotic support for healthy ageing

The global population is ageing faster than ever before. In 2019, life expectancy at birth reached 72.8 years almost 9 years more than in 1990. In this context, staying healthy

22 December 2025
Sacco System grows in Latin America: BioInsumos in Uruguay and Sacco Brasil acquired.

The Group is accelerating its South American growth strategy through a twofold transaction: the acquisition of a Uruguayan company and the full absorption of its Brazilian subsidiary. The Group is

11 December 2025
Sacco System Presents PerforMilk®: Unlocking Milk’s Full Potential by Preserving Protein Quality 

Milk is the most precious resource in dairy production. High-quality dairy products start with high-quality milk—and in today’s rapidly evolving dairy landscape, protecting that quality has never been more critical. 

20 November 2025
Unveiling the survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model

“Survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model” is the title of the study that has been

07 February 2025
L. rhamnosus CA15 Achieves GRAS Status: A Milestone for Women’s Health

GRAS (Generally Recognised as Safe) is a designation by the US Food and Drug Administration (FDA) that indicates that a substance is considered safe based on expert consensus or a

08 January 2025
Sacco System Australia’s Heat-Inactivated Postbiotics Receive Positive Recommendations from FSANZ

Brisbane, 8 January 2025 Sacco System Australia, a leader in innovative probiotic and postbiotic solutions, is proud to announce that L. rhamnosus CRL 1505 HI (heat-inactivated) and Lactobacillus acidophilus LA1

25 November 2024
News
Our 2023 sustainability report is online!

We are proud to present the fifth edition of our Sustainability Report, an opportunity to reflect on the milestones achieved and the challenges ahead…

16 April 2024
News
Sacco System is pleased to announce the grand opening of its development site in Australia.

Today in the presence of Luna Angelini Marinucci, from 2022 the Consul of Italy in Brisbane, with territorial jurisdiction over the State of Queensland…

26 March 2024
News
Sacco System companies have been awarded as Sustainability champions by Ecovadis

At Sacco System we have always put Sustainability at the very core of our activities and our commitment, which is why we are proud that our companies Caglificio Clerici…

18 March 2024
News
List Biotherapeutics and Sacco System Announce Lead Share Agreement

List Biotherapeutics, Inc. (List Bio) and Sacco System Australia Pty Ltd (Sacco) today announced a lead share agreement…

26 February 2024
News
CSL FRANCE becomes SACCO SYSTEM FRANCE

Sacco System is the international biotechnological company dedicated to the food, nutraceutical, and pharmaceutical industries…

We are pleased to announce that we are launching a new starter culture in your market.


The product name is Yo-mild and will be suitable for stirred, diluted and drinking yoghurt for extra-mild applications.
Yo-mild was developed with a focus on low post-acidification activity in storage and it is characterized by a very high sweetness perception and optimal milky flavour.

Attached resources

Latest News

19 March 2026
A regulatory achievement for Sacco System: our Heat-Inactivated CRL1505® receives GRAS status

An important regulatory goal has been achieved with the conclusion reached by an independent expert panel for the self-affirmed GRAS (Generally Recognized as Safe) determination of our postbiotic CRL1505® HI.

24 January 2026
SYNBIO®: Sacco System’s probiotic support for healthy ageing

The global population is ageing faster than ever before. In 2019, life expectancy at birth reached 72.8 years almost 9 years more than in 1990. In this context, staying healthy

22 December 2025
Sacco System grows in Latin America: BioInsumos in Uruguay and Sacco Brasil acquired.

The Group is accelerating its South American growth strategy through a twofold transaction: the acquisition of a Uruguayan company and the full absorption of its Brazilian subsidiary. The Group is

11 December 2025
Sacco System Presents PerforMilk®: Unlocking Milk’s Full Potential by Preserving Protein Quality 

Milk is the most precious resource in dairy production. High-quality dairy products start with high-quality milk—and in today’s rapidly evolving dairy landscape, protecting that quality has never been more critical. 

20 November 2025
Unveiling the survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model

“Survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model” is the title of the study that has been

07 February 2025
L. rhamnosus CA15 Achieves GRAS Status: A Milestone for Women’s Health

GRAS (Generally Recognised as Safe) is a designation by the US Food and Drug Administration (FDA) that indicates that a substance is considered safe based on expert consensus or a

08 January 2025
Sacco System Australia’s Heat-Inactivated Postbiotics Receive Positive Recommendations from FSANZ

Brisbane, 8 January 2025 Sacco System Australia, a leader in innovative probiotic and postbiotic solutions, is proud to announce that L. rhamnosus CRL 1505 HI (heat-inactivated) and Lactobacillus acidophilus LA1

25 November 2024
News
Our 2023 sustainability report is online!

We are proud to present the fifth edition of our Sustainability Report, an opportunity to reflect on the milestones achieved and the challenges ahead…

16 April 2024
News
Sacco System is pleased to announce the grand opening of its development site in Australia.

Today in the presence of Luna Angelini Marinucci, from 2022 the Consul of Italy in Brisbane, with territorial jurisdiction over the State of Queensland…

26 March 2024
News
Sacco System companies have been awarded as Sustainability champions by Ecovadis

At Sacco System we have always put Sustainability at the very core of our activities and our commitment, which is why we are proud that our companies Caglificio Clerici…

18 March 2024
News
List Biotherapeutics and Sacco System Announce Lead Share Agreement

List Biotherapeutics, Inc. (List Bio) and Sacco System Australia Pty Ltd (Sacco) today announced a lead share agreement…

26 February 2024
News
CSL FRANCE becomes SACCO SYSTEM FRANCE

Sacco System is the international biotechnological company dedicated to the food, nutraceutical, and pharmaceutical industries…

In memory of Antonio Cava.

It was 1986 when we met Antonio Cava at the Cibus Tec trade show, who was working at PBI at the time providing services to the dairy and healthcare industries.

When he arrived at the company on April 1 of that year, he was given the task of building a sales network for Italy, for the ferments division and for labware. Antonio enthusiastically accepted the challenge, creating a team that throughout the peninsula has taken Sacco inside many companies with collaborations that continue today and have allowed the group to grow and improve.

Great technical expertise, a strong commercial spirit, intuition, passion and tireless optimism have always distinguished Antonio, who throughout his career has managed to find the best solution even in the most difficult situations with great competence and initiative.

We will fondly remember an estimable man of great intelligence and a great asset to our company.

Famiglia Verga

Latest News

19 March 2026
A regulatory achievement for Sacco System: our Heat-Inactivated CRL1505® receives GRAS status

An important regulatory goal has been achieved with the conclusion reached by an independent expert panel for the self-affirmed GRAS (Generally Recognized as Safe) determination of our postbiotic CRL1505® HI.

24 January 2026
SYNBIO®: Sacco System’s probiotic support for healthy ageing

The global population is ageing faster than ever before. In 2019, life expectancy at birth reached 72.8 years almost 9 years more than in 1990. In this context, staying healthy

22 December 2025
Sacco System grows in Latin America: BioInsumos in Uruguay and Sacco Brasil acquired.

The Group is accelerating its South American growth strategy through a twofold transaction: the acquisition of a Uruguayan company and the full absorption of its Brazilian subsidiary. The Group is

11 December 2025
Sacco System Presents PerforMilk®: Unlocking Milk’s Full Potential by Preserving Protein Quality 

Milk is the most precious resource in dairy production. High-quality dairy products start with high-quality milk—and in today’s rapidly evolving dairy landscape, protecting that quality has never been more critical. 

20 November 2025
Unveiling the survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model

“Survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model” is the title of the study that has been

07 February 2025
L. rhamnosus CA15 Achieves GRAS Status: A Milestone for Women’s Health

GRAS (Generally Recognised as Safe) is a designation by the US Food and Drug Administration (FDA) that indicates that a substance is considered safe based on expert consensus or a

08 January 2025
Sacco System Australia’s Heat-Inactivated Postbiotics Receive Positive Recommendations from FSANZ

Brisbane, 8 January 2025 Sacco System Australia, a leader in innovative probiotic and postbiotic solutions, is proud to announce that L. rhamnosus CRL 1505 HI (heat-inactivated) and Lactobacillus acidophilus LA1

25 November 2024
News
Our 2023 sustainability report is online!

We are proud to present the fifth edition of our Sustainability Report, an opportunity to reflect on the milestones achieved and the challenges ahead…

16 April 2024
News
Sacco System is pleased to announce the grand opening of its development site in Australia.

Today in the presence of Luna Angelini Marinucci, from 2022 the Consul of Italy in Brisbane, with territorial jurisdiction over the State of Queensland…

26 March 2024
News
Sacco System companies have been awarded as Sustainability champions by Ecovadis

At Sacco System we have always put Sustainability at the very core of our activities and our commitment, which is why we are proud that our companies Caglificio Clerici…

18 March 2024
News
List Biotherapeutics and Sacco System Announce Lead Share Agreement

List Biotherapeutics, Inc. (List Bio) and Sacco System Australia Pty Ltd (Sacco) today announced a lead share agreement…

26 February 2024
News
CSL FRANCE becomes SACCO SYSTEM FRANCE

Sacco System is the international biotechnological company dedicated to the food, nutraceutical, and pharmaceutical industries…

CSL USA INC. opens new fermentation facility to produce food ingredients and cultures, bacterial cultures, and probiotics for use in dairy, food, dietary supplements, pharma, and agriculture.


Franksville, Wisconsin, USA: Today, CSL USA INC. (Cultures Supporting Life), an independent entity, is born with the intention of offering new technology solutions to meet the growing needs of the US biotechnology market. CSL USA announces the opening of its new custom fermentation facility, located in Franksville, Wisconsin. The 80,000 sq. ft. facility will support the growing Food, Beverage, Health, and Nutrition markets.
CSL USA will have access to strains and technologies developed by Sacco System (Milan, Italy) over its 150 years of history.
Sacco System produces food ingredients including food cultures, bacterial cultures, and probiotics, for the dairy, food, dietary supplements, pharma, and agriculture markets since 1872. Sacco System is also one of the largest contract fermentation organizations in the world.


As an official technology partner to Sacco System, CSL USA enters the market with a strong platform of science and a long history of fermentation experience. CSL USA will promote the full line of food ingredients, food cultures, bacterial cultures, probiotics, and comprehensive fermentation services to customers in the US. This business association will provide mutual benefits to CSL USA and Sacco System, and most importantly, to our customers today and long into the future.

Kyle Griffiths, Vice President of Sales & Marketing for CSL USA said in a written statement, “The new CSL USA production facilities located in the United States will increase our flexibility to serve the needs of US customers, while increasing the global capacity for our worldwide customer base. We believe that the creation of CSL USA will accelerate our efforts to grow in both the health and nutrition and the food and beverage markets globally as we bring new products and service to the US marketplace”.

For Information contact info@cslusa.com

Latest News

19 March 2026
A regulatory achievement for Sacco System: our Heat-Inactivated CRL1505® receives GRAS status

An important regulatory goal has been achieved with the conclusion reached by an independent expert panel for the self-affirmed GRAS (Generally Recognized as Safe) determination of our postbiotic CRL1505® HI.

24 January 2026
SYNBIO®: Sacco System’s probiotic support for healthy ageing

The global population is ageing faster than ever before. In 2019, life expectancy at birth reached 72.8 years almost 9 years more than in 1990. In this context, staying healthy

22 December 2025
Sacco System grows in Latin America: BioInsumos in Uruguay and Sacco Brasil acquired.

The Group is accelerating its South American growth strategy through a twofold transaction: the acquisition of a Uruguayan company and the full absorption of its Brazilian subsidiary. The Group is

11 December 2025
Sacco System Presents PerforMilk®: Unlocking Milk’s Full Potential by Preserving Protein Quality 

Milk is the most precious resource in dairy production. High-quality dairy products start with high-quality milk—and in today’s rapidly evolving dairy landscape, protecting that quality has never been more critical. 

20 November 2025
Unveiling the survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model

“Survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model” is the title of the study that has been

07 February 2025
L. rhamnosus CA15 Achieves GRAS Status: A Milestone for Women’s Health

GRAS (Generally Recognised as Safe) is a designation by the US Food and Drug Administration (FDA) that indicates that a substance is considered safe based on expert consensus or a

08 January 2025
Sacco System Australia’s Heat-Inactivated Postbiotics Receive Positive Recommendations from FSANZ

Brisbane, 8 January 2025 Sacco System Australia, a leader in innovative probiotic and postbiotic solutions, is proud to announce that L. rhamnosus CRL 1505 HI (heat-inactivated) and Lactobacillus acidophilus LA1

25 November 2024
News
Our 2023 sustainability report is online!

We are proud to present the fifth edition of our Sustainability Report, an opportunity to reflect on the milestones achieved and the challenges ahead…

16 April 2024
News
Sacco System is pleased to announce the grand opening of its development site in Australia.

Today in the presence of Luna Angelini Marinucci, from 2022 the Consul of Italy in Brisbane, with territorial jurisdiction over the State of Queensland…

26 March 2024
News
Sacco System companies have been awarded as Sustainability champions by Ecovadis

At Sacco System we have always put Sustainability at the very core of our activities and our commitment, which is why we are proud that our companies Caglificio Clerici…

18 March 2024
News
List Biotherapeutics and Sacco System Announce Lead Share Agreement

List Biotherapeutics, Inc. (List Bio) and Sacco System Australia Pty Ltd (Sacco) today announced a lead share agreement…

26 February 2024
News
CSL FRANCE becomes SACCO SYSTEM FRANCE

Sacco System is the international biotechnological company dedicated to the food, nutraceutical, and pharmaceutical industries…

Caglificio Clerici celebrates its 150th anniversary this year.

Industry, culture, community support and continuous innovation to guarantee, since 1872, the best ingredients for cheesemakers from all over the world.

Corporate culture, financial soundness, sustainability and tradition have allowed the historic Caglificio of the Verga family to cross more than a century with resilience and stability, guaranteeing for five generations, natural ingredients, sought after 100% Made in Italy for the production of cheeses and dairy products in more than 110 countries around the world.

Caglificio Clerici has been with pride for 150 years, the only rennet that loves your milk.

Latest News

19 March 2026
A regulatory achievement for Sacco System: our Heat-Inactivated CRL1505® receives GRAS status

An important regulatory goal has been achieved with the conclusion reached by an independent expert panel for the self-affirmed GRAS (Generally Recognized as Safe) determination of our postbiotic CRL1505® HI.

24 January 2026
SYNBIO®: Sacco System’s probiotic support for healthy ageing

The global population is ageing faster than ever before. In 2019, life expectancy at birth reached 72.8 years almost 9 years more than in 1990. In this context, staying healthy

22 December 2025
Sacco System grows in Latin America: BioInsumos in Uruguay and Sacco Brasil acquired.

The Group is accelerating its South American growth strategy through a twofold transaction: the acquisition of a Uruguayan company and the full absorption of its Brazilian subsidiary. The Group is

11 December 2025
Sacco System Presents PerforMilk®: Unlocking Milk’s Full Potential by Preserving Protein Quality 

Milk is the most precious resource in dairy production. High-quality dairy products start with high-quality milk—and in today’s rapidly evolving dairy landscape, protecting that quality has never been more critical. 

20 November 2025
Unveiling the survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model

“Survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model” is the title of the study that has been

07 February 2025
L. rhamnosus CA15 Achieves GRAS Status: A Milestone for Women’s Health

GRAS (Generally Recognised as Safe) is a designation by the US Food and Drug Administration (FDA) that indicates that a substance is considered safe based on expert consensus or a

08 January 2025
Sacco System Australia’s Heat-Inactivated Postbiotics Receive Positive Recommendations from FSANZ

Brisbane, 8 January 2025 Sacco System Australia, a leader in innovative probiotic and postbiotic solutions, is proud to announce that L. rhamnosus CRL 1505 HI (heat-inactivated) and Lactobacillus acidophilus LA1

25 November 2024
News
Our 2023 sustainability report is online!

We are proud to present the fifth edition of our Sustainability Report, an opportunity to reflect on the milestones achieved and the challenges ahead…

16 April 2024
News
Sacco System is pleased to announce the grand opening of its development site in Australia.

Today in the presence of Luna Angelini Marinucci, from 2022 the Consul of Italy in Brisbane, with territorial jurisdiction over the State of Queensland…

26 March 2024
News
Sacco System companies have been awarded as Sustainability champions by Ecovadis

At Sacco System we have always put Sustainability at the very core of our activities and our commitment, which is why we are proud that our companies Caglificio Clerici…

18 March 2024
News
List Biotherapeutics and Sacco System Announce Lead Share Agreement

List Biotherapeutics, Inc. (List Bio) and Sacco System Australia Pty Ltd (Sacco) today announced a lead share agreement…

26 February 2024
News
CSL FRANCE becomes SACCO SYSTEM FRANCE

Sacco System is the international biotechnological company dedicated to the food, nutraceutical, and pharmaceutical industries…

Sacco System, the international biotech pole operating in the food, nutraceutical and pharmaceutical industries is now bringing its vast decades of experience to the nordic countries with the rebranding of the subsidiary Sacco System Nordic AB, formerly known as Kemikalia AB.

Kemikalia, now Sacco System Nordic, was established as a private company back in 1914 in Malmö. Cheese rennet and butter colour were the signature products of the company from the very beginning, and so they continued to be for many years to follow. During the Second World War, Kemikalia was acquired in 1942 by SMR (Swedish Dairies National Association) with the primary aim to ensure the supply of cheese rennet for the Swedish dairy companies.

In 2006 with its new headquarter in Skurup, Kemikalia was sold to Caglificio Clerici, a member of what has become today’s Sacco System. Later in 2021, the ownership structure of Kemikalia underwent a series of changes that resulted in the Verga family in Italy becoming the majority owner. As a result, Kemikalia became part of the Sacco System, owned by the Verga family.

Starting from the first of May 2022, after 108 years of activity, Kemikalia will change its name to Sacco System Nordic AB, and thus officially become a full subsidiary of Sacco System for the nordic countries.

To further strengthen its presence in the nordic countries, SACCO SYSTEM has appointed Mr Anders Olsson as CEO, who led the company in the latest years.

“We have had good cooperation with Sacco, Caglificio Clerici and Centro Sperimentale del Latte for many years, now we become part of the Sacco System for real. This strengthens us as a company as we can offer a larger product range and, thanks to Sacco System´s research and development department, better service to both existing and new customers. We will be Sacco Systems’ Nordic base and we look forward to a strong development for our company and our cooperation with the Nordic market” says Anders Olsson. “The creation of the Sacco System Nordic subsidiary is a welcome addition to the Sacco System Group of companies. By having a permanent presence in these countries, we will be able to give our partners strong support and increase our business development activities in the dairy cultures, plant-based alternative fermented products, probiotics and vitamin market. This is an exciting step for our 150-year family company and we look forward to supporting our clients in the Nordic countries with our high-quality products and services”, says Mrs Iris Verga, member of the board of directors of Sacco System Nordic.

Latest News

19 March 2026
A regulatory achievement for Sacco System: our Heat-Inactivated CRL1505® receives GRAS status

An important regulatory goal has been achieved with the conclusion reached by an independent expert panel for the self-affirmed GRAS (Generally Recognized as Safe) determination of our postbiotic CRL1505® HI.

24 January 2026
SYNBIO®: Sacco System’s probiotic support for healthy ageing

The global population is ageing faster than ever before. In 2019, life expectancy at birth reached 72.8 years almost 9 years more than in 1990. In this context, staying healthy

22 December 2025
Sacco System grows in Latin America: BioInsumos in Uruguay and Sacco Brasil acquired.

The Group is accelerating its South American growth strategy through a twofold transaction: the acquisition of a Uruguayan company and the full absorption of its Brazilian subsidiary. The Group is

11 December 2025
Sacco System Presents PerforMilk®: Unlocking Milk’s Full Potential by Preserving Protein Quality 

Milk is the most precious resource in dairy production. High-quality dairy products start with high-quality milk—and in today’s rapidly evolving dairy landscape, protecting that quality has never been more critical. 

20 November 2025
Unveiling the survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model

“Survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model” is the title of the study that has been

07 February 2025
L. rhamnosus CA15 Achieves GRAS Status: A Milestone for Women’s Health

GRAS (Generally Recognised as Safe) is a designation by the US Food and Drug Administration (FDA) that indicates that a substance is considered safe based on expert consensus or a

08 January 2025
Sacco System Australia’s Heat-Inactivated Postbiotics Receive Positive Recommendations from FSANZ

Brisbane, 8 January 2025 Sacco System Australia, a leader in innovative probiotic and postbiotic solutions, is proud to announce that L. rhamnosus CRL 1505 HI (heat-inactivated) and Lactobacillus acidophilus LA1

25 November 2024
News
Our 2023 sustainability report is online!

We are proud to present the fifth edition of our Sustainability Report, an opportunity to reflect on the milestones achieved and the challenges ahead…

16 April 2024
News
Sacco System is pleased to announce the grand opening of its development site in Australia.

Today in the presence of Luna Angelini Marinucci, from 2022 the Consul of Italy in Brisbane, with territorial jurisdiction over the State of Queensland…

26 March 2024
News
Sacco System companies have been awarded as Sustainability champions by Ecovadis

At Sacco System we have always put Sustainability at the very core of our activities and our commitment, which is why we are proud that our companies Caglificio Clerici…

18 March 2024
News
List Biotherapeutics and Sacco System Announce Lead Share Agreement

List Biotherapeutics, Inc. (List Bio) and Sacco System Australia Pty Ltd (Sacco) today announced a lead share agreement…

26 February 2024
News
CSL FRANCE becomes SACCO SYSTEM FRANCE

Sacco System is the international biotechnological company dedicated to the food, nutraceutical, and pharmaceutical industries…

After years of research and experimentation in the field, Sacco System is finally ready to launch a new selection of natural formulations ideated for the bio-stimulation and bio-protection of plants.

This new project is part of a larger agronomic and environmental policy-set (Farm to Fork and Green Deal), which aim to reduce the use of chemically synthesised products.

Sacco System’s team of researchers and technicians have developed a large portfolio of formulations and raw materials to meet the application and technological needs of its customers in the agro-livestock sector.

Sacco System offers its expertise to its partners, providing technological consultancy also for experimental projects aiming to develop new products, perfect or expand the existing product portfolio and innovate the commercial offer with new, cutting-edge, top-notch technologies and ingredients.

These microorganisms promote plant growth, improve the well-being of the crop, with proven benefits in terms of efficacy, eco-sustainability, adaptability and yield increase, through the strengthening of all the defence and development mechanisms of the plants.

The new agronomic revolution of Sacco System springs from a large collection of microorganisms (strain bank), constantly developed and consolidated thanks to numerous partnerships with customers and research centres.

Development of biostimulants and bio-fungicides: the products of the Nutrilia line

Starting from the selection of microorganisms in vitro and the study of their physiological characteristics, their effectiveness is carefully evaluated with a view to maximizing their productivity in the field. An example of this is the array of products falling under the Nutrilia line, tailored to improve plant nutrition through the use of growth-promoting microorganisms.

Nutrilia A (Nutrition boost)

A mixture of mycorrhizae and nitrogen-fixing bacteria, capable of supplying the necessary nitrogen to plants and of concomitantly ensuring a balanced level of nutrients without chemical-physical alterations to the soil.

Target crop: Vegetables, Row crops, Fruit plants, Ornamental plants, Greenhouse plants, Strawberries.
Applications: Fertigation, Sowing, Transplanting, Cover fertilization, Compost integration.

Target crop: Vegetables, Row crops, Fruit plants, Ornamental plants, Greenhouse plants, Strawberries
Applications: Fertigation, Sowing, Transplanting, Cover fertilization, Compost integration.

Nutrilia B (Energy boost)

A mixture of mycorrhizae and phosphorus solubilizing bacteria, essential for the energetic and nutritional balance of plants and positively influences their photosynthesis, vigour and resistance to abiotic stress.

Target crop: Vegetables, Row crops, Fruit plants, Ornamental plants, Greenhouse plants, Strawberries

Target crop: Vegetables, Row crops, Fruit plants, Ornamental plants, Greenhouse plants, Strawberries
Applications: Fertigation, Sowing, Transplanting, Cover fertilization, Compost integration.

Nutrilia P (Growth boost)

A mixture of mycorrhizae and Pseudomonas produce plant hormones, which have a direct impact on the plant’s growth as well as on the accumulation of fresh biomass.

Target crop: Vegetables, Row crops, Fruit plants, Ornamental plants, Greenhouse plants, Strawberries

Applications: Fertigation, Sowing, Transplanting, Cover fertilization, Compost integration.

Partnerships with Contract Research Organizations

To validate the effectiveness of its products, Sacco System collaborates with industry specialists such as CROs (Contract Research Organizations) and then proceeds with registration and distribution.

Our solution for a more sustainable economy

Sacco System firmly believes in the importance of sustainable actions to minimize its environmental impact, including through the study and production of natural microorganisms intended for use in agriculture and for the well-being of plants in lieu of chemical alternatives.

Sacco System’s AgroVet business unit offers not only microorganisms conceived to maximise the well-being and health of plants but also for the application to animal care and for the subsequent maximisation of the animals’ well-being through the creation of products capable of exploiting the natural mechanisms and beneficial interactions present in nature.

For more information: info@saccosystem.com

19 March 2026
A regulatory achievement for Sacco System: our Heat-Inactivated CRL1505® receives GRAS status

An important regulatory goal has been achieved with the conclusion reached by an independent expert panel for the self-affirmed GRAS (Generally Recognized as Safe) determination of our postbiotic CRL1505® HI.

24 January 2026
SYNBIO®: Sacco System’s probiotic support for healthy ageing

The global population is ageing faster than ever before. In 2019, life expectancy at birth reached 72.8 years almost 9 years more than in 1990. In this context, staying healthy

22 December 2025
Sacco System grows in Latin America: BioInsumos in Uruguay and Sacco Brasil acquired.

The Group is accelerating its South American growth strategy through a twofold transaction: the acquisition of a Uruguayan company and the full absorption of its Brazilian subsidiary. The Group is

11 December 2025
Sacco System Presents PerforMilk®: Unlocking Milk’s Full Potential by Preserving Protein Quality 

Milk is the most precious resource in dairy production. High-quality dairy products start with high-quality milk—and in today’s rapidly evolving dairy landscape, protecting that quality has never been more critical. 

20 November 2025
Unveiling the survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model

“Survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model” is the title of the study that has been

07 February 2025
L. rhamnosus CA15 Achieves GRAS Status: A Milestone for Women’s Health

GRAS (Generally Recognised as Safe) is a designation by the US Food and Drug Administration (FDA) that indicates that a substance is considered safe based on expert consensus or a

08 January 2025
Sacco System Australia’s Heat-Inactivated Postbiotics Receive Positive Recommendations from FSANZ

Brisbane, 8 January 2025 Sacco System Australia, a leader in innovative probiotic and postbiotic solutions, is proud to announce that L. rhamnosus CRL 1505 HI (heat-inactivated) and Lactobacillus acidophilus LA1

25 November 2024
News
Our 2023 sustainability report is online!

We are proud to present the fifth edition of our Sustainability Report, an opportunity to reflect on the milestones achieved and the challenges ahead…

16 April 2024
News
Sacco System is pleased to announce the grand opening of its development site in Australia.

Today in the presence of Luna Angelini Marinucci, from 2022 the Consul of Italy in Brisbane, with territorial jurisdiction over the State of Queensland…

26 March 2024
News
Sacco System companies have been awarded as Sustainability champions by Ecovadis

At Sacco System we have always put Sustainability at the very core of our activities and our commitment, which is why we are proud that our companies Caglificio Clerici…

18 March 2024
News
List Biotherapeutics and Sacco System Announce Lead Share Agreement

List Biotherapeutics, Inc. (List Bio) and Sacco System Australia Pty Ltd (Sacco) today announced a lead share agreement…

26 February 2024
News
CSL FRANCE becomes SACCO SYSTEM FRANCE

Sacco System is the international biotechnological company dedicated to the food, nutraceutical, and pharmaceutical industries…

Sacco, one of the leading and most historically relevant biotech companies in both research and the production of lactic bacteria and probiotics for the food, nutraceutical and pharmaceutical industries, has recently acquired the majority of Synbiotec, a spin-off company of the University of Camerino specialized in the research and development of probiotics for applications in human and animal nutrition.

The potential synergies between these two companies are numerous: both share the strategic goal of contributing to the improvement of both humans’ and animals’ welfare through the study, research and development of natural ingredients and processes; and both commit to supplying probiotic bacterial strains with the highest levels of quality and innovation always keeping in tune with the demands of a constantly evolving market.

“We are deeply convinced that the synergies existing between the two companies, which have over time had the chance to get to know each other, and which are further reinforced through this acquisition, will lead to the landmark establishment of a pole of excellence in the Italian industry of probiotics for human and animal health. This will also undoubtedly favour research, development and innovation in the production and improvement of products for the well-being of consumers. Another shared fundamental pillar for both companies, which paves the ground for virtuous cooperation, is the cardinal importance both assign to human capital for the achievement of their core goals.” says Martino Verga, CEO of Sacco Srl.

“We are thrilled to be able to share our probiotic research experience with a large international group like Sacco. The strength of its history and its global presence will allow us to explore together new applications for the probiotic market with the shared intention of improving the health and well-being of consumers. The participation of the Sacco group in Synbiotec is a great opportunity for our company, and I am sure it will help us grow and further establish ourselves in the market”, says Maria Cristina Verdenelli, President and Founding Partner of Synbiotec.

Latest News

19 March 2026
A regulatory achievement for Sacco System: our Heat-Inactivated CRL1505® receives GRAS status

An important regulatory goal has been achieved with the conclusion reached by an independent expert panel for the self-affirmed GRAS (Generally Recognized as Safe) determination of our postbiotic CRL1505® HI.

24 January 2026
SYNBIO®: Sacco System’s probiotic support for healthy ageing

The global population is ageing faster than ever before. In 2019, life expectancy at birth reached 72.8 years almost 9 years more than in 1990. In this context, staying healthy

22 December 2025
Sacco System grows in Latin America: BioInsumos in Uruguay and Sacco Brasil acquired.

The Group is accelerating its South American growth strategy through a twofold transaction: the acquisition of a Uruguayan company and the full absorption of its Brazilian subsidiary. The Group is

11 December 2025
Sacco System Presents PerforMilk®: Unlocking Milk’s Full Potential by Preserving Protein Quality 

Milk is the most precious resource in dairy production. High-quality dairy products start with high-quality milk—and in today’s rapidly evolving dairy landscape, protecting that quality has never been more critical. 

20 November 2025
Unveiling the survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model

“Survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model” is the title of the study that has been

07 February 2025
L. rhamnosus CA15 Achieves GRAS Status: A Milestone for Women’s Health

GRAS (Generally Recognised as Safe) is a designation by the US Food and Drug Administration (FDA) that indicates that a substance is considered safe based on expert consensus or a

08 January 2025
Sacco System Australia’s Heat-Inactivated Postbiotics Receive Positive Recommendations from FSANZ

Brisbane, 8 January 2025 Sacco System Australia, a leader in innovative probiotic and postbiotic solutions, is proud to announce that L. rhamnosus CRL 1505 HI (heat-inactivated) and Lactobacillus acidophilus LA1

25 November 2024
News
Our 2023 sustainability report is online!

We are proud to present the fifth edition of our Sustainability Report, an opportunity to reflect on the milestones achieved and the challenges ahead…

16 April 2024
News
Sacco System is pleased to announce the grand opening of its development site in Australia.

Today in the presence of Luna Angelini Marinucci, from 2022 the Consul of Italy in Brisbane, with territorial jurisdiction over the State of Queensland…

26 March 2024
News
Sacco System companies have been awarded as Sustainability champions by Ecovadis

At Sacco System we have always put Sustainability at the very core of our activities and our commitment, which is why we are proud that our companies Caglificio Clerici…

18 March 2024
News
List Biotherapeutics and Sacco System Announce Lead Share Agreement

List Biotherapeutics, Inc. (List Bio) and Sacco System Australia Pty Ltd (Sacco) today announced a lead share agreement…

26 February 2024
News
CSL FRANCE becomes SACCO SYSTEM FRANCE

Sacco System is the international biotechnological company dedicated to the food, nutraceutical, and pharmaceutical industries…

We have published our second sustainability report, with the aim of communicating in full transparency the environmental, social and economic performance to all stakeholders, describing the initiatives undertaken and the results achieved in 2020.

During this year, the new coronavirus pandemic has had a tremendous impact on our lives and the way we work. The health emergency has also made it clear that scientific research and innovation are the strongest weapons in helping us to face the challenges of the present and the future. It also demonstrated how much environmental, social and economic systems are intimately connected and interdependent.

It is necessary to keep the focus on sustainability, to help the transition to a better future in which everyone – individuals, communities, companies and institutions – work together to improve social and natural well-being. commitment, allowing us to monitor the progress of our performance, to highlight critical issues and strengths and to modulate our efforts and our commitment accordingly, to minimize negative impacts and maximize positive ones.

Indeed, the 2020 sustainability report represents for us not only an important communication tool and connection with all our stakeholders but also a fundamental control dashboard through which to have an overview of our actions that contribute to the sustainable development of the environment. in which we operate.

Latest News

19 March 2026
A regulatory achievement for Sacco System: our Heat-Inactivated CRL1505® receives GRAS status

An important regulatory goal has been achieved with the conclusion reached by an independent expert panel for the self-affirmed GRAS (Generally Recognized as Safe) determination of our postbiotic CRL1505® HI.

24 January 2026
SYNBIO®: Sacco System’s probiotic support for healthy ageing

The global population is ageing faster than ever before. In 2019, life expectancy at birth reached 72.8 years almost 9 years more than in 1990. In this context, staying healthy

22 December 2025
Sacco System grows in Latin America: BioInsumos in Uruguay and Sacco Brasil acquired.

The Group is accelerating its South American growth strategy through a twofold transaction: the acquisition of a Uruguayan company and the full absorption of its Brazilian subsidiary. The Group is

11 December 2025
Sacco System Presents PerforMilk®: Unlocking Milk’s Full Potential by Preserving Protein Quality 

Milk is the most precious resource in dairy production. High-quality dairy products start with high-quality milk—and in today’s rapidly evolving dairy landscape, protecting that quality has never been more critical. 

20 November 2025
Unveiling the survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model

“Survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model” is the title of the study that has been

07 February 2025
L. rhamnosus CA15 Achieves GRAS Status: A Milestone for Women’s Health

GRAS (Generally Recognised as Safe) is a designation by the US Food and Drug Administration (FDA) that indicates that a substance is considered safe based on expert consensus or a

08 January 2025
Sacco System Australia’s Heat-Inactivated Postbiotics Receive Positive Recommendations from FSANZ

Brisbane, 8 January 2025 Sacco System Australia, a leader in innovative probiotic and postbiotic solutions, is proud to announce that L. rhamnosus CRL 1505 HI (heat-inactivated) and Lactobacillus acidophilus LA1

25 November 2024
News
Our 2023 sustainability report is online!

We are proud to present the fifth edition of our Sustainability Report, an opportunity to reflect on the milestones achieved and the challenges ahead…

16 April 2024
News
Sacco System is pleased to announce the grand opening of its development site in Australia.

Today in the presence of Luna Angelini Marinucci, from 2022 the Consul of Italy in Brisbane, with territorial jurisdiction over the State of Queensland…

26 March 2024
News
Sacco System companies have been awarded as Sustainability champions by Ecovadis

At Sacco System we have always put Sustainability at the very core of our activities and our commitment, which is why we are proud that our companies Caglificio Clerici…

18 March 2024
News
List Biotherapeutics and Sacco System Announce Lead Share Agreement

List Biotherapeutics, Inc. (List Bio) and Sacco System Australia Pty Ltd (Sacco) today announced a lead share agreement…

26 February 2024
News
CSL FRANCE becomes SACCO SYSTEM FRANCE

Sacco System is the international biotechnological company dedicated to the food, nutraceutical, and pharmaceutical industries…

Döhler and Sacco System are pleased to announce their strategic partnership in the area of plant-based dairy alternatives and food cultures. This partnership will boost the development and success rate of new products and brands in this dynamic and growing market segment.

Fermented foods have been consumed by humans for over 10 thousand years already. Today, consumers have developed distinct taste and texture preferences that vary by region and by country. Moreover, plant-based food products imply the introduction within the industry of various new raw materials with different underlying tastes, textures, and processing needs, while consumers, on their side will not compromise on taste. Producers are challenged to work with numerous new ingredients, complex formulations and multiple suppliers, which is both time-consuming and may even represent a risk for the successful launch of new products.

This is the challenge that the Sacco System and Döhler partnership is set out to address. The cooperation between the two companies has been focused on the mapping of possible solutions and on the identification of winning combinations that are ready to be deployed. On top of that, both companies will jointly continue working on innovative products as well as next-level taste and texture performances.


Sacco System, the international biotech company for the food, nutraceutical, and pharmaceutical industries, and Döhler, global producer, marketer and provider of technology-driven natural ingredients, ingredient systems and integrated solutions for the food and beverage industry, now join forces to develop new innovative, clean label and 100% natural solutions for the plant-based dairy alternatives food market.

R&D, innovation, and attention to the latest market trends are some of the fundamental pillars shared by both companies.

Sacco truly believes in this exciting partnership which will facilitate shared mutual experiences in plant-based knowledge, thereby creating additional strength and market value for both companies.

Carlo Appennini, Dairy BU Executive Director of Sacco System


“We are excited about this partnership as Sacco is a renowned company in the space of cultures, and bringing cultures to Döhler plant-based dairy alternatives will complete the offering. Customers will get the entire science needed to run successful fermented plant-based projects with decreased time-to-market.”

Martin Sonntag, Member of Board of the DOEHLER GROUP

__________________________________________________________________


About Döhler

Döhler (www.doehler.com) is a global producer, marketer and provider of technology-driven natural ingredients, ingredient systems and integrated solutions for the food and beverage industry. Döhler’s integrated approach and the broad product portfolio are the optimal basis for innovative and safe food & beverage applications. The product portfolio of natural ingredients ranges from natural flavours, natural colours, health ingredients, pulses & cereal ingredients, dairy & plant-based ingredients, fermented ingredients, dry fruit & vegetable ingredients, fruit & vegetable ingredients to ingredient systems.

Headquartered in Darmstadt, Germany, Döhler is active in over 130 countries and has more than 40 production sites, as well as sales offices and application centres on every continent. More than 7,000 dedicated employees provide our customers with fully integrated food & beverage solutions from concept to realisation.

“WE BRING IDEAS TO LIFE.” briefly describes Döhler’s holistic, strategic and entrepreneurial approach to innovation. This comprises market intelligence, trend monitoring, the development of innovative products and product applications, advice on food safety and microbiology, food law as well as Sensory & Consumer Science.

doehler.com

Latest News

19 March 2026
A regulatory achievement for Sacco System: our Heat-Inactivated CRL1505® receives GRAS status

An important regulatory goal has been achieved with the conclusion reached by an independent expert panel for the self-affirmed GRAS (Generally Recognized as Safe) determination of our postbiotic CRL1505® HI.

24 January 2026
SYNBIO®: Sacco System’s probiotic support for healthy ageing

The global population is ageing faster than ever before. In 2019, life expectancy at birth reached 72.8 years almost 9 years more than in 1990. In this context, staying healthy

22 December 2025
Sacco System grows in Latin America: BioInsumos in Uruguay and Sacco Brasil acquired.

The Group is accelerating its South American growth strategy through a twofold transaction: the acquisition of a Uruguayan company and the full absorption of its Brazilian subsidiary. The Group is

11 December 2025
Sacco System Presents PerforMilk®: Unlocking Milk’s Full Potential by Preserving Protein Quality 

Milk is the most precious resource in dairy production. High-quality dairy products start with high-quality milk—and in today’s rapidly evolving dairy landscape, protecting that quality has never been more critical. 

20 November 2025
Unveiling the survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model

“Survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model” is the title of the study that has been

07 February 2025
L. rhamnosus CA15 Achieves GRAS Status: A Milestone for Women’s Health

GRAS (Generally Recognised as Safe) is a designation by the US Food and Drug Administration (FDA) that indicates that a substance is considered safe based on expert consensus or a

08 January 2025
Sacco System Australia’s Heat-Inactivated Postbiotics Receive Positive Recommendations from FSANZ

Brisbane, 8 January 2025 Sacco System Australia, a leader in innovative probiotic and postbiotic solutions, is proud to announce that L. rhamnosus CRL 1505 HI (heat-inactivated) and Lactobacillus acidophilus LA1

25 November 2024
News
Our 2023 sustainability report is online!

We are proud to present the fifth edition of our Sustainability Report, an opportunity to reflect on the milestones achieved and the challenges ahead…

16 April 2024
News
Sacco System is pleased to announce the grand opening of its development site in Australia.

Today in the presence of Luna Angelini Marinucci, from 2022 the Consul of Italy in Brisbane, with territorial jurisdiction over the State of Queensland…

26 March 2024
News
Sacco System companies have been awarded as Sustainability champions by Ecovadis

At Sacco System we have always put Sustainability at the very core of our activities and our commitment, which is why we are proud that our companies Caglificio Clerici…

18 March 2024
News
List Biotherapeutics and Sacco System Announce Lead Share Agreement

List Biotherapeutics, Inc. (List Bio) and Sacco System Australia Pty Ltd (Sacco) today announced a lead share agreement…

26 February 2024
News
CSL FRANCE becomes SACCO SYSTEM FRANCE

Sacco System is the international biotechnological company dedicated to the food, nutraceutical, and pharmaceutical industries…

Not everyone knows that lactic bacteria are excellent allies for the leavening of baked goods and many realities have begun to use them as a substitute for yeast.

Using lactic cultures in the production of bakery products has a dual function: it allows you to replace the brewer’s yeast and at the same time obtain bakery products with the typical taste of “old-time bread“.

Lactic acid bacteria for leavening: how they work and what are the advantages

The use of lactic acid bacteria for leavening has a lot of advantages. First of all, unlike yeasts, lactic bacteria do not have allergens and therefore do not cause food intolerances at any extra dosage.

They develop an acid type fermentation, an alternative to that of brewer’s yeast which is alcoholic, which leads to the production of gas (CO2) and the ionization of some mineral salts, thus improving their bioavailability and therefore the assimilation of essential micronutrients such as magnesium, iron, zinc and calcium by our body.

Furthermore, some strains of lactic bacteria can produce antimicrobial substances resistant to high temperatures useful for improving the healthiness of the product and increasing its shelf-life.

Finally, thanks to their enzymatic and fermentation activity on the dough, the lactic bacteria give the consumer a more digestible and healthy product, suitable for all ages.

With these premises it is easy to understand that thanks to lactic bacteria it is possible to reduce or eliminate the use of brewer’s yeast as a leavening agent. In the latter case, the product will be safe even for people intolerant to yeasts and will be characterized by the claim “no added yeasts”.

Let’s not forget that lactic bacteria improve the product from a sensorial point of view, giving the unmistakable flavor and aroma of “old-time bread” and improving the color of the crust and crumb.

Sacco System has selected the best lactic bacteria from mother yeast, creating an ad hoc product, the Fermento Padre™, which is suitable for baking by completely replacing the brewer’s yeast. These enzymes are excellent for the production of baked goods such as pizza, bread and confectionery products and can also be used for the fermentation of gluten-free products.

How to use Fermento Padre in the baking process

The Fermento Padre™ in powder can be used in a very simple way: adding it during the baking process exactly as you do with an instant yeast.

From today you can see how simple it is to use Fermento Padre™ in the bread and pizza making process thanks to the Libero Impastatore Andrea Pioppi; you can watch how to make bread and pizza with Fermento Padre™ by clicking here.

Fermento Padre™ allows you to make bread directly and also to delay the process of staling the product: the presence of organic acids improves the shelf life of the product as these act as anti-mold, increasing its shelf-life.

In conclusion, we can say that the Fermento Padre™ is a real revolution in the bakery world able to give us innovative bakery products but with an ancient taste!
The product is available for both professional and home use.

With Fermento Padre™, a new era of baking begins!

For more information: info@saccosystem.com

Latest News

19 March 2026
A regulatory achievement for Sacco System: our Heat-Inactivated CRL1505® receives GRAS status

An important regulatory goal has been achieved with the conclusion reached by an independent expert panel for the self-affirmed GRAS (Generally Recognized as Safe) determination of our postbiotic CRL1505® HI.

24 January 2026
SYNBIO®: Sacco System’s probiotic support for healthy ageing

The global population is ageing faster than ever before. In 2019, life expectancy at birth reached 72.8 years almost 9 years more than in 1990. In this context, staying healthy

22 December 2025
Sacco System grows in Latin America: BioInsumos in Uruguay and Sacco Brasil acquired.

The Group is accelerating its South American growth strategy through a twofold transaction: the acquisition of a Uruguayan company and the full absorption of its Brazilian subsidiary. The Group is

11 December 2025
Sacco System Presents PerforMilk®: Unlocking Milk’s Full Potential by Preserving Protein Quality 

Milk is the most precious resource in dairy production. High-quality dairy products start with high-quality milk—and in today’s rapidly evolving dairy landscape, protecting that quality has never been more critical. 

20 November 2025
Unveiling the survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model

“Survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model” is the title of the study that has been

07 February 2025
L. rhamnosus CA15 Achieves GRAS Status: A Milestone for Women’s Health

GRAS (Generally Recognised as Safe) is a designation by the US Food and Drug Administration (FDA) that indicates that a substance is considered safe based on expert consensus or a

08 January 2025
Sacco System Australia’s Heat-Inactivated Postbiotics Receive Positive Recommendations from FSANZ

Brisbane, 8 January 2025 Sacco System Australia, a leader in innovative probiotic and postbiotic solutions, is proud to announce that L. rhamnosus CRL 1505 HI (heat-inactivated) and Lactobacillus acidophilus LA1

25 November 2024
News
Our 2023 sustainability report is online!

We are proud to present the fifth edition of our Sustainability Report, an opportunity to reflect on the milestones achieved and the challenges ahead…

16 April 2024
News
Sacco System is pleased to announce the grand opening of its development site in Australia.

Today in the presence of Luna Angelini Marinucci, from 2022 the Consul of Italy in Brisbane, with territorial jurisdiction over the State of Queensland…

26 March 2024
News
Sacco System companies have been awarded as Sustainability champions by Ecovadis

At Sacco System we have always put Sustainability at the very core of our activities and our commitment, which is why we are proud that our companies Caglificio Clerici…

18 March 2024
News
List Biotherapeutics and Sacco System Announce Lead Share Agreement

List Biotherapeutics, Inc. (List Bio) and Sacco System Australia Pty Ltd (Sacco) today announced a lead share agreement…

26 February 2024
News
CSL FRANCE becomes SACCO SYSTEM FRANCE

Sacco System is the international biotechnological company dedicated to the food, nutraceutical, and pharmaceutical industries…

Evolve BioSystems, Inc. is the manufacturer of Evivo®, a proprietary groundbreaking probiotic proven to resolve Newborn Gut Deficiency, which studies have shown affects more than 90% of babies in the U.S. Evivo contains activated B. infantis EVC001 which restores key bacteria to the infant’s gut and guides critical development of infant’s digestive and immune system. Evivo works by favourably altering gut biochemistry to reduce potentially pathogenic bacteria by 80 per cent which in turn significantly reduces intestinal inflammation. Those pathogens and the inflammation which they cause are linked to a higher risk of both short- and long-term health issues including colic, diaper rash, eczema, asthma, allergies and even Type 1 Diabetes.

Martino Verga, CEO Sacco System
“We are impressed by the science that Evolve has done, and are excited to be within the European investors in Evolve. We believe in the mission of Evolve because our company CSL was the first company in Italy to study Lactic Acid Bacteria for human health.
One of Sacco System pillars is creative intelligence, with a focus on R&D and innovation. For this reason, we are proud to be a partner with Evolve, a company dedicated to developing the next generation of probiotics to improve life and wellbeing.
We strongly trust that there is always a probiotic that makes your life better”.
Sacco System and its reputation as a highly professional manufacturer of probiotics and other live biotherapeutics will support an investment that will help Evolve BioSystems, Inc in bringing Evivo® Baby Probiotic to Europe.

Tim Brown, CEO Evolve BioSystems, Inc.
“We are pleased to add Sacco to the growing list of investors in Evolve” said Tim Brown, CEO of Evolve BioSystems, “This investment from major Italian corporations signals the interest in Evolve’s proprietary product lines on a global Basis”.

Latest News

19 March 2026
A regulatory achievement for Sacco System: our Heat-Inactivated CRL1505® receives GRAS status

An important regulatory goal has been achieved with the conclusion reached by an independent expert panel for the self-affirmed GRAS (Generally Recognized as Safe) determination of our postbiotic CRL1505® HI.

24 January 2026
SYNBIO®: Sacco System’s probiotic support for healthy ageing

The global population is ageing faster than ever before. In 2019, life expectancy at birth reached 72.8 years almost 9 years more than in 1990. In this context, staying healthy

22 December 2025
Sacco System grows in Latin America: BioInsumos in Uruguay and Sacco Brasil acquired.

The Group is accelerating its South American growth strategy through a twofold transaction: the acquisition of a Uruguayan company and the full absorption of its Brazilian subsidiary. The Group is

11 December 2025
Sacco System Presents PerforMilk®: Unlocking Milk’s Full Potential by Preserving Protein Quality 

Milk is the most precious resource in dairy production. High-quality dairy products start with high-quality milk—and in today’s rapidly evolving dairy landscape, protecting that quality has never been more critical. 

20 November 2025
Unveiling the survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model

“Survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model” is the title of the study that has been

07 February 2025
L. rhamnosus CA15 Achieves GRAS Status: A Milestone for Women’s Health

GRAS (Generally Recognised as Safe) is a designation by the US Food and Drug Administration (FDA) that indicates that a substance is considered safe based on expert consensus or a

08 January 2025
Sacco System Australia’s Heat-Inactivated Postbiotics Receive Positive Recommendations from FSANZ

Brisbane, 8 January 2025 Sacco System Australia, a leader in innovative probiotic and postbiotic solutions, is proud to announce that L. rhamnosus CRL 1505 HI (heat-inactivated) and Lactobacillus acidophilus LA1

25 November 2024
News
Our 2023 sustainability report is online!

We are proud to present the fifth edition of our Sustainability Report, an opportunity to reflect on the milestones achieved and the challenges ahead…

16 April 2024
News
Sacco System is pleased to announce the grand opening of its development site in Australia.

Today in the presence of Luna Angelini Marinucci, from 2022 the Consul of Italy in Brisbane, with territorial jurisdiction over the State of Queensland…

26 March 2024
News
Sacco System companies have been awarded as Sustainability champions by Ecovadis

At Sacco System we have always put Sustainability at the very core of our activities and our commitment, which is why we are proud that our companies Caglificio Clerici…

18 March 2024
News
List Biotherapeutics and Sacco System Announce Lead Share Agreement

List Biotherapeutics, Inc. (List Bio) and Sacco System Australia Pty Ltd (Sacco) today announced a lead share agreement…

26 February 2024
News
CSL FRANCE becomes SACCO SYSTEM FRANCE

Sacco System is the international biotechnological company dedicated to the food, nutraceutical, and pharmaceutical industries…

“Modern Agricultural innovation relies on sustainability and preservation of ecological balances. Our alliance with Landlab aims to develop innovative, sustainable and eco-friendly products, supported by the most rigorous and careful efficacy trials because we know that the success and the effectiveness of our products, depends on the health and the happiness of our Nature, our consumers and our future generations.” Francesco Vuolo, R&D researcher.

Landlab is a cutting-edge research team, a place for pure thoughts, development and innovation for agriculture, active in this area for more than 20 years.
Steadily growing in the last decade, constantly changing, including new people from different cultures, origins and scientific backgrounds, Landlab knows how to renew, innovate, by investing in resources and technologies. We develop products intended for sustainable agriculture.

We deal with national and international global players but always focus on high value, efficient, environmentally sound solutions.
Our job is based on research, constant training, on pursue scientific quality, innovation of methods and techniques. Landlab promotes every individual as a professional bearing skill, know-how and values. We demand commitment, dedication, a spirit of cooperation, passion and creativity.

We deal with plants nutrition, bio-stimulation and protection, by developing new products with special care for the changes of this sector.

Therefore the long term agreement, partnership, with Sacco System is perfectly fitting our way of thinking and working, our spirit. We do trust in the value of networking where each node, each individual, free-thinking but strongly joint with the others has the best possibility to create innovative solutions.

Soil life has to be dramatically enhanced since it has been almost forgotten in the last years. Microbials, bacteria, yeasts will therefore have a growing role in this direction by promoting soil stability and the plants’ wellbeing. Precisely identified Microbials consortia combined with balanced nutrition will be of high value in the robustness and performance of the crop.

We think that single tools, single players are not the solution, but only a far more holistic approach will better promote the maximum yield potential of the crops. Integration, combination, contamination, hybridization: key values for a truly progressive research flow. Therefore we were looking, for years, for a reliable partner in the plant-soil-microbiome area, for establishing long-term oriented cooperation. For three years Landlab and Sacco System have in place several research projects. From here we decided to move ahead and establish a stable joint innovation platform.
“We are now fully convinced: Landlab & SACCO SYSTEM are on the same page, both devoted to going through this new and very promising path”, says Adriano Altissimo, Co-Owner Landlab

Attached resources

Latest News

19 March 2026
A regulatory achievement for Sacco System: our Heat-Inactivated CRL1505® receives GRAS status

An important regulatory goal has been achieved with the conclusion reached by an independent expert panel for the self-affirmed GRAS (Generally Recognized as Safe) determination of our postbiotic CRL1505® HI.

24 January 2026
SYNBIO®: Sacco System’s probiotic support for healthy ageing

The global population is ageing faster than ever before. In 2019, life expectancy at birth reached 72.8 years almost 9 years more than in 1990. In this context, staying healthy

22 December 2025
Sacco System grows in Latin America: BioInsumos in Uruguay and Sacco Brasil acquired.

The Group is accelerating its South American growth strategy through a twofold transaction: the acquisition of a Uruguayan company and the full absorption of its Brazilian subsidiary. The Group is

11 December 2025
Sacco System Presents PerforMilk®: Unlocking Milk’s Full Potential by Preserving Protein Quality 

Milk is the most precious resource in dairy production. High-quality dairy products start with high-quality milk—and in today’s rapidly evolving dairy landscape, protecting that quality has never been more critical. 

20 November 2025
Unveiling the survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model

“Survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model” is the title of the study that has been

07 February 2025
L. rhamnosus CA15 Achieves GRAS Status: A Milestone for Women’s Health

GRAS (Generally Recognised as Safe) is a designation by the US Food and Drug Administration (FDA) that indicates that a substance is considered safe based on expert consensus or a

08 January 2025
Sacco System Australia’s Heat-Inactivated Postbiotics Receive Positive Recommendations from FSANZ

Brisbane, 8 January 2025 Sacco System Australia, a leader in innovative probiotic and postbiotic solutions, is proud to announce that L. rhamnosus CRL 1505 HI (heat-inactivated) and Lactobacillus acidophilus LA1

25 November 2024
News
Our 2023 sustainability report is online!

We are proud to present the fifth edition of our Sustainability Report, an opportunity to reflect on the milestones achieved and the challenges ahead…

16 April 2024
News
Sacco System is pleased to announce the grand opening of its development site in Australia.

Today in the presence of Luna Angelini Marinucci, from 2022 the Consul of Italy in Brisbane, with territorial jurisdiction over the State of Queensland…

26 March 2024
News
Sacco System companies have been awarded as Sustainability champions by Ecovadis

At Sacco System we have always put Sustainability at the very core of our activities and our commitment, which is why we are proud that our companies Caglificio Clerici…

18 March 2024
News
List Biotherapeutics and Sacco System Announce Lead Share Agreement

List Biotherapeutics, Inc. (List Bio) and Sacco System Australia Pty Ltd (Sacco) today announced a lead share agreement…

26 February 2024
News
CSL FRANCE becomes SACCO SYSTEM FRANCE

Sacco System is the international biotechnological company dedicated to the food, nutraceutical, and pharmaceutical industries…

The growing diffusion of intensive crops, boosted by and paired with the ever-increasing demand for them, have forced agriculture to resort to the employment of substantial doses of synthetic products to obtain ever-greater yields.
This ongoing pattern has been taking the exploitation of soils to the extreme, corrupting the balance of these ecosystems. All of this has indeed caused substantial damage to the chemical-physical qualities of the soils, heightening the risk of contamination of the aquifers and of reduction in the ability of cultivated plants to access nutrients.

Sacco System proposes the use of completely natural microbial species selected, following their million-year long evolution process, to be specifically associated with crops. This plant-bacterium association is essential to ensure and maintain the well-being and protection of plants. The integration of specific microbial crops in agriculture will prospectively lead to the achievement of even greater yields concerning the current ones, but pursued in an eco-sustainable, natural and healthy way.

Sacco System began its research activity for the Plant sector, dedicated to the care and nutrition of plants, in June 2018, setting out four main objectives to pursue:

  • Development of a collection of bacteria capable of bio-stimulating plant growth, and/or protecting plants from harmful pathogens.
  • Establishing technical, commercial and communication relationships with leading companies in plant bio-stimulation / biocontrol, and develop new products in cooperation with them.
  • Creation of prototypes of fertilizers and biocontrol agents for the agricultural sector.
  • Offering consultancy and technical support services to companies producing bio-stimulants and bio-fungicides for the improvement of their portfolio.

Creation of a cell bank for the Agro sector

The process that led to the creation of the cell bank for application on plants began with the study of the sector-specific scientific literature, followed by in-depth laboratory work, starting from fertile and agronomically valid soils, to isolate and analyse new bacteria.
The ensuing results were boosted through the use of cutting-edge techniques, which guaranteed the possibility to identify all the positive properties of the newly isolated microorganisms, while ensuring the most high-standard biological safety, in compliance with the development strategies of the European Commission as crystallized in the “From Farm to Fork” plan.

In the full spirit of research and innovation that distinguishes Sacco System, we have intensified our network of collaborations with many national and international universities to give more breadth and perspective to our work of research and discovery.

Partnerships and customers

Sacco System developed a well-nurtured network of collaborations and communication exchanges with several leading companies in the field of fertilizers and bio-fungicides; besides, the relationship with some of these companies has moved one step further as the possibility of carrying out conjoint product development using the bacteria from our “Agro library” is currently under discussion.

Other companies, on the other hand, are interested in establishing a supply relationship for their fermented strains specifically to increase their production scale (custom fermentation service).

This varied and multifunctional network is essential to support the expansion of our corporate outreach, and at the same time learn, while remaining creative and innovative.
Our centenary experience in the production field has indeed been put to the service of safeguarding the plant world, enriching itself in the process thanks to the exposure to new notions and perspectives.

Prototype development

The Research & Development department of this sector is specifically characterised by the thriving development of new products and the definition of new projects as an essential peculiarity.
In addition to the selection of microorganisms in vitro, the study of their physiological characteristics, it is vital to carefully evaluate their effectiveness in the field.
This process of assessment takes place both within dedicated company structures (in the greenhouse and the growth rooms), and by resorting to the service sector specialists such as CROs (Contract Research Organizations).
These structures play a key role as they allow to produce proofs of effectiveness of the prototypes, possibly contribute to the drafting of the registration dossier, as well as partake in the effort to reach the best possible formulation to make the final product more effective.

These same structures can also function as a network of companies, connecting Sacco System prototypes to large distributors and vice versa.

Sacco System firmly believes in the importance of sustainable actions to reduce the environmental impact of agriculture, among other things also through the study and production of natural microorganisms in agriculture and for the well-being of plants.

Latest News

19 March 2026
A regulatory achievement for Sacco System: our Heat-Inactivated CRL1505® receives GRAS status

An important regulatory goal has been achieved with the conclusion reached by an independent expert panel for the self-affirmed GRAS (Generally Recognized as Safe) determination of our postbiotic CRL1505® HI.

24 January 2026
SYNBIO®: Sacco System’s probiotic support for healthy ageing

The global population is ageing faster than ever before. In 2019, life expectancy at birth reached 72.8 years almost 9 years more than in 1990. In this context, staying healthy

22 December 2025
Sacco System grows in Latin America: BioInsumos in Uruguay and Sacco Brasil acquired.

The Group is accelerating its South American growth strategy through a twofold transaction: the acquisition of a Uruguayan company and the full absorption of its Brazilian subsidiary. The Group is

11 December 2025
Sacco System Presents PerforMilk®: Unlocking Milk’s Full Potential by Preserving Protein Quality 

Milk is the most precious resource in dairy production. High-quality dairy products start with high-quality milk—and in today’s rapidly evolving dairy landscape, protecting that quality has never been more critical. 

20 November 2025
Unveiling the survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model

“Survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model” is the title of the study that has been

07 February 2025
L. rhamnosus CA15 Achieves GRAS Status: A Milestone for Women’s Health

GRAS (Generally Recognised as Safe) is a designation by the US Food and Drug Administration (FDA) that indicates that a substance is considered safe based on expert consensus or a

08 January 2025
Sacco System Australia’s Heat-Inactivated Postbiotics Receive Positive Recommendations from FSANZ

Brisbane, 8 January 2025 Sacco System Australia, a leader in innovative probiotic and postbiotic solutions, is proud to announce that L. rhamnosus CRL 1505 HI (heat-inactivated) and Lactobacillus acidophilus LA1

25 November 2024
News
Our 2023 sustainability report is online!

We are proud to present the fifth edition of our Sustainability Report, an opportunity to reflect on the milestones achieved and the challenges ahead…

16 April 2024
News
Sacco System is pleased to announce the grand opening of its development site in Australia.

Today in the presence of Luna Angelini Marinucci, from 2022 the Consul of Italy in Brisbane, with territorial jurisdiction over the State of Queensland…

26 March 2024
News
Sacco System companies have been awarded as Sustainability champions by Ecovadis

At Sacco System we have always put Sustainability at the very core of our activities and our commitment, which is why we are proud that our companies Caglificio Clerici…

18 March 2024
News
List Biotherapeutics and Sacco System Announce Lead Share Agreement

List Biotherapeutics, Inc. (List Bio) and Sacco System Australia Pty Ltd (Sacco) today announced a lead share agreement…

26 February 2024
News
CSL FRANCE becomes SACCO SYSTEM FRANCE

Sacco System is the international biotechnological company dedicated to the food, nutraceutical, and pharmaceutical industries…

Almost five years after the creation of the Sacco System business network, today we are glad to communicate the birth of Sacco System Holding srl: a new corporate structure for which the Verga family plans to forge additional group synergies with a view to achieving structured international growth within the next few years.

Currently, the group includes four companies – Caglificio Clerici spa, Sacco srl, Centro Sperimentale del Latte srl, and Kemikalia AB.
With this new corporate structure, it intends to face the challenge of development at an international level, placing itself in the market with an even greater value not only in terms of economic activity and equity, but also of brand and therefore of business.

The increasingly open desire for innovation and international growth has led the owners to implement this new corporate structure without precluding other choices in the future.

With an aggregate turnover of more than 130 million euros, the companies headed by Sacco System Holding srl, have been able to conquer increasingly dominant positions in the market of enzymes, bacteria and probiotic cultures.

The people of Sacco System will continue to be fundamental in achieving the ambitious goals of the next years, positioning themselves in the biotechnology market in a profitable way with an increasingly stronger and more recognizable brand.

Sacco System: International group, Family spirit.

Latest News

19 March 2026
A regulatory achievement for Sacco System: our Heat-Inactivated CRL1505® receives GRAS status

An important regulatory goal has been achieved with the conclusion reached by an independent expert panel for the self-affirmed GRAS (Generally Recognized as Safe) determination of our postbiotic CRL1505® HI.

24 January 2026
SYNBIO®: Sacco System’s probiotic support for healthy ageing

The global population is ageing faster than ever before. In 2019, life expectancy at birth reached 72.8 years almost 9 years more than in 1990. In this context, staying healthy

22 December 2025
Sacco System grows in Latin America: BioInsumos in Uruguay and Sacco Brasil acquired.

The Group is accelerating its South American growth strategy through a twofold transaction: the acquisition of a Uruguayan company and the full absorption of its Brazilian subsidiary. The Group is

11 December 2025
Sacco System Presents PerforMilk®: Unlocking Milk’s Full Potential by Preserving Protein Quality 

Milk is the most precious resource in dairy production. High-quality dairy products start with high-quality milk—and in today’s rapidly evolving dairy landscape, protecting that quality has never been more critical. 

20 November 2025
Unveiling the survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model

“Survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model” is the title of the study that has been

07 February 2025
L. rhamnosus CA15 Achieves GRAS Status: A Milestone for Women’s Health

GRAS (Generally Recognised as Safe) is a designation by the US Food and Drug Administration (FDA) that indicates that a substance is considered safe based on expert consensus or a

08 January 2025
Sacco System Australia’s Heat-Inactivated Postbiotics Receive Positive Recommendations from FSANZ

Brisbane, 8 January 2025 Sacco System Australia, a leader in innovative probiotic and postbiotic solutions, is proud to announce that L. rhamnosus CRL 1505 HI (heat-inactivated) and Lactobacillus acidophilus LA1

25 November 2024
News
Our 2023 sustainability report is online!

We are proud to present the fifth edition of our Sustainability Report, an opportunity to reflect on the milestones achieved and the challenges ahead…

16 April 2024
News
Sacco System is pleased to announce the grand opening of its development site in Australia.

Today in the presence of Luna Angelini Marinucci, from 2022 the Consul of Italy in Brisbane, with territorial jurisdiction over the State of Queensland…

26 March 2024
News
Sacco System companies have been awarded as Sustainability champions by Ecovadis

At Sacco System we have always put Sustainability at the very core of our activities and our commitment, which is why we are proud that our companies Caglificio Clerici…

18 March 2024
News
List Biotherapeutics and Sacco System Announce Lead Share Agreement

List Biotherapeutics, Inc. (List Bio) and Sacco System Australia Pty Ltd (Sacco) today announced a lead share agreement…

26 February 2024
News
CSL FRANCE becomes SACCO SYSTEM FRANCE

Sacco System is the international biotechnological company dedicated to the food, nutraceutical, and pharmaceutical industries…

Interview with Luigi Rossi

Sacco System has decided to reorganize its Agro-food division by proposing new product lines, inserting new qualified personnel and giving the leadership of the BU to Dr Luigi Rossi, a man with great experience in the development of sales networks and business start-ups worldwide.

To get to know this new structure better, we interviewed Dr Rossi.

Dr Rossi, you have worked for decades in the Dairy business. What prompted you to accept the challenge to change the sector and shift focus on the Agro-food world? What exactly is meant by Agro-food?

My Dairy team and I have experienced exciting years, during which we have built a worldwide network by selecting the best distribution channels and sharing with them a partnership path that has allowed business developments in more than 110 countries around the world.

The new role of Commercial Director of the Agro-food Business Unit has a particularly important significance to me. By leveraging my accumulated experience, I will give my contribution to positioning Sacco System in new emerging sectors that foresees very important growth trends in the upcoming years.

The new Agro-food BU is made up of several market segments, all of which are nonetheless characterized by one important element they share, namely the innovation and enhancement of our microorganisms as an added value to our customers’ production processes.

The probiotics we offer for the Plants and livestock sector allow, in addition to improving the health of plants and animals, to increase yields by reducing, or in many cases even eliminating, the use of antibiotics, pesticides, chemical fertilizers. We are fully aware of the relevance this element carries in the choice made by the final consumer.

The meat sector will also enjoy the benefit of improving the production and shelf life of its products through the use of our protective cultures.

The company is also expanding its interest to explore other areas such as fermented food and the beverage sector, experimenting with cultures that improve the aroma of fruit-based drinks, and the production of bread and other baked products.

Research and development have always been a fundamental pillar for Sacco, also in light of our growth-oriented mentality. For what concerns the plant sector, the company has recently signed a collaboration agreement with a technological platform, Landlab, to cooperate in the testing of innovative microorganisms, both in vitro (greenhouse) and directly in the field.

You mention an impressively wide range of applications for the use of cultures and probiotics: from meat to fish, bread, vegetables and fermented drinks. What prompted you to expand the product portfolio?

All of our customers, in the various sectors mentioned, have as a primary interest in the production of goods characterized by high safety levels. Keeping this main goal in mind, our process and protection crops allow us to obtain stable fermentation, avoiding the deterioration of the product thanks to a “natural flora”, which becomes the antagonist of unwanted microorganisms, such as Listeria monocytogenes.

Cultures can also be used as an alternative to yeast for consumers who wish to switch to a diet without added yeasts; a real revolution for yeast-intolerant people, and even more so for gourmets, continuously in search of particular products reminiscing of the ancestral tastes of leavened bread and cakes.

The use of our crops has therefore become “transversal” to multiple sectors, ranging from the dairy sector to many other markets in the food and agri-food sector.

Which markets are you targeting?

Certainly, Italy remains a country in focus, especially for the cured meat sector. However, we always keep an eye on the world and on global trends, such as the great increase in the demand for fermented beverages, “dairy alternative” beverages, as well as the greater care and attention being paid to the overall well-being of plants and animals.
We will target our offer to the B2B sector by designing with it not only commercial development but also a development network made up of qualified technical application personnel.
For each sector we have technical specialists who also have specific technical application expertise, thus providing a consultancy service, which could be easily defined as “from start to finish
”.

What about the future?

I would say that there are already many applications we are working on right now, but we also know that it is essential to never stop and always try to innovate.

For more information:

info@saccosystem.com

Latest News

19 March 2026
A regulatory achievement for Sacco System: our Heat-Inactivated CRL1505® receives GRAS status

An important regulatory goal has been achieved with the conclusion reached by an independent expert panel for the self-affirmed GRAS (Generally Recognized as Safe) determination of our postbiotic CRL1505® HI.

24 January 2026
SYNBIO®: Sacco System’s probiotic support for healthy ageing

The global population is ageing faster than ever before. In 2019, life expectancy at birth reached 72.8 years almost 9 years more than in 1990. In this context, staying healthy

22 December 2025
Sacco System grows in Latin America: BioInsumos in Uruguay and Sacco Brasil acquired.

The Group is accelerating its South American growth strategy through a twofold transaction: the acquisition of a Uruguayan company and the full absorption of its Brazilian subsidiary. The Group is

11 December 2025
Sacco System Presents PerforMilk®: Unlocking Milk’s Full Potential by Preserving Protein Quality 

Milk is the most precious resource in dairy production. High-quality dairy products start with high-quality milk—and in today’s rapidly evolving dairy landscape, protecting that quality has never been more critical. 

20 November 2025
Unveiling the survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model

“Survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model” is the title of the study that has been

07 February 2025
L. rhamnosus CA15 Achieves GRAS Status: A Milestone for Women’s Health

GRAS (Generally Recognised as Safe) is a designation by the US Food and Drug Administration (FDA) that indicates that a substance is considered safe based on expert consensus or a

08 January 2025
Sacco System Australia’s Heat-Inactivated Postbiotics Receive Positive Recommendations from FSANZ

Brisbane, 8 January 2025 Sacco System Australia, a leader in innovative probiotic and postbiotic solutions, is proud to announce that L. rhamnosus CRL 1505 HI (heat-inactivated) and Lactobacillus acidophilus LA1

25 November 2024
News
Our 2023 sustainability report is online!

We are proud to present the fifth edition of our Sustainability Report, an opportunity to reflect on the milestones achieved and the challenges ahead…

16 April 2024
News
Sacco System is pleased to announce the grand opening of its development site in Australia.

Today in the presence of Luna Angelini Marinucci, from 2022 the Consul of Italy in Brisbane, with territorial jurisdiction over the State of Queensland…

26 March 2024
News
Sacco System companies have been awarded as Sustainability champions by Ecovadis

At Sacco System we have always put Sustainability at the very core of our activities and our commitment, which is why we are proud that our companies Caglificio Clerici…

18 March 2024
News
List Biotherapeutics and Sacco System Announce Lead Share Agreement

List Biotherapeutics, Inc. (List Bio) and Sacco System Australia Pty Ltd (Sacco) today announced a lead share agreement…

26 February 2024
News
CSL FRANCE becomes SACCO SYSTEM FRANCE

Sacco System is the international biotechnological company dedicated to the food, nutraceutical, and pharmaceutical industries…

We are happy to announce that Centro Sperimentale del Latte’s Z2 has been authorized by AIFA to produce pharmaceutical-grade freeze-dried cultures.

In a nutshell, pharmaceutical-grade products require high-standard quality systems to be in place, as well as structures, equipment, and processes that guarantee high and consistent quality productions.
Above all, this achievement was the result of hard work and a great team effort by many groups within our company:

  • The Quality Assurance team managed all regulatory aspects, including application, preparation, and submission of GMP procedures, equipment qualification, process validation, etc., interface with the authorities, and overall monitoring of the project.
  • The Production team was in charge of operations such as preparation and collection of plant documentation, executing tests, interface with suppliers, and drafting of relevant procedures, among others.
  • The Quality Control team provided its support in the development of the quality control plan, executing the sampling and analyses necessary for qualifications and validations, etc.

This certification marks another great step on the path to growth that Centro Sperimentale del Latte started some years ago, with the objective to deliver high-quality probiotic cultures and to be a player in the pharmaceutical business worldwide.

Latest News

19 March 2026
A regulatory achievement for Sacco System: our Heat-Inactivated CRL1505® receives GRAS status

An important regulatory goal has been achieved with the conclusion reached by an independent expert panel for the self-affirmed GRAS (Generally Recognized as Safe) determination of our postbiotic CRL1505® HI.

24 January 2026
SYNBIO®: Sacco System’s probiotic support for healthy ageing

The global population is ageing faster than ever before. In 2019, life expectancy at birth reached 72.8 years almost 9 years more than in 1990. In this context, staying healthy

22 December 2025
Sacco System grows in Latin America: BioInsumos in Uruguay and Sacco Brasil acquired.

The Group is accelerating its South American growth strategy through a twofold transaction: the acquisition of a Uruguayan company and the full absorption of its Brazilian subsidiary. The Group is

11 December 2025
Sacco System Presents PerforMilk®: Unlocking Milk’s Full Potential by Preserving Protein Quality 

Milk is the most precious resource in dairy production. High-quality dairy products start with high-quality milk—and in today’s rapidly evolving dairy landscape, protecting that quality has never been more critical. 

20 November 2025
Unveiling the survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model

“Survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model” is the title of the study that has been

07 February 2025
L. rhamnosus CA15 Achieves GRAS Status: A Milestone for Women’s Health

GRAS (Generally Recognised as Safe) is a designation by the US Food and Drug Administration (FDA) that indicates that a substance is considered safe based on expert consensus or a

08 January 2025
Sacco System Australia’s Heat-Inactivated Postbiotics Receive Positive Recommendations from FSANZ

Brisbane, 8 January 2025 Sacco System Australia, a leader in innovative probiotic and postbiotic solutions, is proud to announce that L. rhamnosus CRL 1505 HI (heat-inactivated) and Lactobacillus acidophilus LA1

25 November 2024
News
Our 2023 sustainability report is online!

We are proud to present the fifth edition of our Sustainability Report, an opportunity to reflect on the milestones achieved and the challenges ahead…

16 April 2024
News
Sacco System is pleased to announce the grand opening of its development site in Australia.

Today in the presence of Luna Angelini Marinucci, from 2022 the Consul of Italy in Brisbane, with territorial jurisdiction over the State of Queensland…

26 March 2024
News
Sacco System companies have been awarded as Sustainability champions by Ecovadis

At Sacco System we have always put Sustainability at the very core of our activities and our commitment, which is why we are proud that our companies Caglificio Clerici…

18 March 2024
News
List Biotherapeutics and Sacco System Announce Lead Share Agreement

List Biotherapeutics, Inc. (List Bio) and Sacco System Australia Pty Ltd (Sacco) today announced a lead share agreement…

26 February 2024
News
CSL FRANCE becomes SACCO SYSTEM FRANCE

Sacco System is the international biotechnological company dedicated to the food, nutraceutical, and pharmaceutical industries…


Are you ready to discover INgredients Town?

INgredients Town is a fantastic city where everything is in turmoil. Here the ingredients come to life as real characters, telling their stories and their characteristics.

You will meet Chimosina and Pepsina, fundamental for the production of cheese or Bulgaricus and Termophilus, responsible for the fermentation of yogurt, but also Rhamnosus SP1 and the Bifidos, powerful probiotic superheroes, and many other characters.

An extraordinary space, where you can get to know the invisible allies – who accompany us every day and have a beneficial effect on the health of humans, animals, and the environment – and learn while having fun, through videos, quizzes, and games.
Visit the website and discover the amazing world of INgredients Town.

Latest News

19 March 2026
A regulatory achievement for Sacco System: our Heat-Inactivated CRL1505® receives GRAS status

An important regulatory goal has been achieved with the conclusion reached by an independent expert panel for the self-affirmed GRAS (Generally Recognized as Safe) determination of our postbiotic CRL1505® HI.

24 January 2026
SYNBIO®: Sacco System’s probiotic support for healthy ageing

The global population is ageing faster than ever before. In 2019, life expectancy at birth reached 72.8 years almost 9 years more than in 1990. In this context, staying healthy

22 December 2025
Sacco System grows in Latin America: BioInsumos in Uruguay and Sacco Brasil acquired.

The Group is accelerating its South American growth strategy through a twofold transaction: the acquisition of a Uruguayan company and the full absorption of its Brazilian subsidiary. The Group is

11 December 2025
Sacco System Presents PerforMilk®: Unlocking Milk’s Full Potential by Preserving Protein Quality 

Milk is the most precious resource in dairy production. High-quality dairy products start with high-quality milk—and in today’s rapidly evolving dairy landscape, protecting that quality has never been more critical. 

20 November 2025
Unveiling the survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model

“Survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model” is the title of the study that has been

07 February 2025
L. rhamnosus CA15 Achieves GRAS Status: A Milestone for Women’s Health

GRAS (Generally Recognised as Safe) is a designation by the US Food and Drug Administration (FDA) that indicates that a substance is considered safe based on expert consensus or a

08 January 2025
Sacco System Australia’s Heat-Inactivated Postbiotics Receive Positive Recommendations from FSANZ

Brisbane, 8 January 2025 Sacco System Australia, a leader in innovative probiotic and postbiotic solutions, is proud to announce that L. rhamnosus CRL 1505 HI (heat-inactivated) and Lactobacillus acidophilus LA1

25 November 2024
News
Our 2023 sustainability report is online!

We are proud to present the fifth edition of our Sustainability Report, an opportunity to reflect on the milestones achieved and the challenges ahead…

16 April 2024
News
Sacco System is pleased to announce the grand opening of its development site in Australia.

Today in the presence of Luna Angelini Marinucci, from 2022 the Consul of Italy in Brisbane, with territorial jurisdiction over the State of Queensland…

26 March 2024
News
Sacco System companies have been awarded as Sustainability champions by Ecovadis

At Sacco System we have always put Sustainability at the very core of our activities and our commitment, which is why we are proud that our companies Caglificio Clerici…

18 March 2024
News
List Biotherapeutics and Sacco System Announce Lead Share Agreement

List Biotherapeutics, Inc. (List Bio) and Sacco System Australia Pty Ltd (Sacco) today announced a lead share agreement…

26 February 2024
News
CSL FRANCE becomes SACCO SYSTEM FRANCE

Sacco System is the international biotechnological company dedicated to the food, nutraceutical, and pharmaceutical industries…

Two years after the creation of the Sustainability and Corporate Social Responsibility unit in Sacco System, we considered it essential to report and share our good practices, impacts, and initial results with all of you.

This report represents the first reflection of our activities and the starting point towards an integrated and continuous vision of our main business processes, operations, and their economic, social and environmental impacts.

The 2019 Sustainability Report describes the main aspects that characterized the business activities of Sacco S.r.l., Caglificio Clerici S.p.A. and Centro Sperimentale del Latte S.r.l. in the financial year 1 January 2019 – 31 December 2019. The set of “territorial” indicators we chose made it possible to monitor some key issues for the quality of life in our area and to measure our contribution as socially responsible companies.

Latest News

19 March 2026
A regulatory achievement for Sacco System: our Heat-Inactivated CRL1505® receives GRAS status

An important regulatory goal has been achieved with the conclusion reached by an independent expert panel for the self-affirmed GRAS (Generally Recognized as Safe) determination of our postbiotic CRL1505® HI.

24 January 2026
SYNBIO®: Sacco System’s probiotic support for healthy ageing

The global population is ageing faster than ever before. In 2019, life expectancy at birth reached 72.8 years almost 9 years more than in 1990. In this context, staying healthy

22 December 2025
Sacco System grows in Latin America: BioInsumos in Uruguay and Sacco Brasil acquired.

The Group is accelerating its South American growth strategy through a twofold transaction: the acquisition of a Uruguayan company and the full absorption of its Brazilian subsidiary. The Group is

11 December 2025
Sacco System Presents PerforMilk®: Unlocking Milk’s Full Potential by Preserving Protein Quality 

Milk is the most precious resource in dairy production. High-quality dairy products start with high-quality milk—and in today’s rapidly evolving dairy landscape, protecting that quality has never been more critical. 

20 November 2025
Unveiling the survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model

“Survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model” is the title of the study that has been

07 February 2025
L. rhamnosus CA15 Achieves GRAS Status: A Milestone for Women’s Health

GRAS (Generally Recognised as Safe) is a designation by the US Food and Drug Administration (FDA) that indicates that a substance is considered safe based on expert consensus or a

08 January 2025
Sacco System Australia’s Heat-Inactivated Postbiotics Receive Positive Recommendations from FSANZ

Brisbane, 8 January 2025 Sacco System Australia, a leader in innovative probiotic and postbiotic solutions, is proud to announce that L. rhamnosus CRL 1505 HI (heat-inactivated) and Lactobacillus acidophilus LA1

25 November 2024
News
Our 2023 sustainability report is online!

We are proud to present the fifth edition of our Sustainability Report, an opportunity to reflect on the milestones achieved and the challenges ahead…

16 April 2024
News
Sacco System is pleased to announce the grand opening of its development site in Australia.

Today in the presence of Luna Angelini Marinucci, from 2022 the Consul of Italy in Brisbane, with territorial jurisdiction over the State of Queensland…

26 March 2024
News
Sacco System companies have been awarded as Sustainability champions by Ecovadis

At Sacco System we have always put Sustainability at the very core of our activities and our commitment, which is why we are proud that our companies Caglificio Clerici…

18 March 2024
News
List Biotherapeutics and Sacco System Announce Lead Share Agreement

List Biotherapeutics, Inc. (List Bio) and Sacco System Australia Pty Ltd (Sacco) today announced a lead share agreement…

26 February 2024
News
CSL FRANCE becomes SACCO SYSTEM FRANCE

Sacco System is the international biotechnological company dedicated to the food, nutraceutical, and pharmaceutical industries…

The administration of probiotics in mothers during pregnancy and after birth has shown several benefits on babies’ health, including the improvement of infant colic. For instance, Limosilactobacillus reuteri (basonym “Lactobacillus reuteri”) LR 92 has demonstrated to positively improve infant colic in the first months of life.

What is infant colic?

Infant colic is a condition affecting about 20% infants younger than 3 months old, and is often described as “excessive crying”. The aetiology is unclear but likely related to psychological and physiological causes.
In children, colic leads to sleeping problems and it can also cause allergies, migraine, attention deficit and hyperactivity as long-term effects.
Moreover, infant colic may also cause sleeping disorders and depression in parents due to the continuous crying and sleepless nights [1-2].

Probiotic LR 92 and babies health: clinical evidence

A randomized, double-blind, placebo-controlled trial was conducted on 145 women (18-49 years old) that consumed capsules of LR 92 (108 CFU/day) or a placebo during the last 4 weeks pregnancy [3]. The babies were then monitored for 4-5 months and:

  • Babies from mothers who received placebo were 2.36 times more likely to have colic
  • The frequency and severity of colic were significantly lower in the intervention group
  • LR 92 intake appeared to be especially beneficial for babies born by C- section

Proposed mechanisms of action

Although a full understanding of how perinatal administration of probiotics improves infant colic is still lacking, several mechanisms have been identified [4-8]:

  • increase levels of anti-inflammatory mediators such as IL-10 and TGF-β in breast milk, which in turn stimulate the gut development and IgA secretion, control inflammation and improve gastrointestinal function
  • improve gut barrier function by stabilizing tight junctions and mucin production
  • promote the production of gamma-aminobutyric acid (GABA), which is the major inhibitory neurotransmitter, and influences behaviour
  • modulate gut microbiota development

___________________________________________________

1. Zeevenhooven J et al (2018). Infant colic: mechanisms and management. Nat Rev Gastroenterol Hepatol. 15(8):479-496
2. https://www.mayoclinic.org/diseases-conditions/colic/symptoms-causes/syc-20371074
3. Pourmirzaiee MA et al. (2020) The efficacy of the prenatal administration of Lactobacillus reuteri LR92 DSM 26866 on the prevention of infantile colic: a randomized control trial. Eur J Pediatr 179, 1619–1626.
4. Sung V et al (2018) Lactobacillus reuteri to Treat Infant Colic: A Meta-analysis. Pediatrics 141(1):e20171811
5. Sohn K and Underwood MA (2017) Prenatal and postnatal administration of prebiotics and probiotics. Semin Fetal Neonatal Med. 22(5): 284–289.
6. Sung V, et al. (2012) Probiotics to improve outcomes of colic in the community: protocol for the Baby Biotics randomised controlled trial. BMC Pediatr. 12:135
7. Baldassarre ME et al (2018) Rationale of Probiotic Supplementation during Pregnancy and Neonatal Period. Nutrients 6;10(11):1693.
8. Grze?kowiak ? et al. (2012) The impact of perinatal probiotic intervention on gut microbiota: double-blind placebo-controlled trials in Finland and Germany. Anaerobe. 2012;18(1):7?13.

Latest News

19 March 2026
A regulatory achievement for Sacco System: our Heat-Inactivated CRL1505® receives GRAS status

An important regulatory goal has been achieved with the conclusion reached by an independent expert panel for the self-affirmed GRAS (Generally Recognized as Safe) determination of our postbiotic CRL1505® HI.

24 January 2026
SYNBIO®: Sacco System’s probiotic support for healthy ageing

The global population is ageing faster than ever before. In 2019, life expectancy at birth reached 72.8 years almost 9 years more than in 1990. In this context, staying healthy

22 December 2025
Sacco System grows in Latin America: BioInsumos in Uruguay and Sacco Brasil acquired.

The Group is accelerating its South American growth strategy through a twofold transaction: the acquisition of a Uruguayan company and the full absorption of its Brazilian subsidiary. The Group is

11 December 2025
Sacco System Presents PerforMilk®: Unlocking Milk’s Full Potential by Preserving Protein Quality 

Milk is the most precious resource in dairy production. High-quality dairy products start with high-quality milk—and in today’s rapidly evolving dairy landscape, protecting that quality has never been more critical. 

20 November 2025
Unveiling the survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model

“Survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model” is the title of the study that has been

07 February 2025
L. rhamnosus CA15 Achieves GRAS Status: A Milestone for Women’s Health

GRAS (Generally Recognised as Safe) is a designation by the US Food and Drug Administration (FDA) that indicates that a substance is considered safe based on expert consensus or a

08 January 2025
Sacco System Australia’s Heat-Inactivated Postbiotics Receive Positive Recommendations from FSANZ

Brisbane, 8 January 2025 Sacco System Australia, a leader in innovative probiotic and postbiotic solutions, is proud to announce that L. rhamnosus CRL 1505 HI (heat-inactivated) and Lactobacillus acidophilus LA1

25 November 2024
News
Our 2023 sustainability report is online!

We are proud to present the fifth edition of our Sustainability Report, an opportunity to reflect on the milestones achieved and the challenges ahead…

16 April 2024
News
Sacco System is pleased to announce the grand opening of its development site in Australia.

Today in the presence of Luna Angelini Marinucci, from 2022 the Consul of Italy in Brisbane, with territorial jurisdiction over the State of Queensland…

26 March 2024
News
Sacco System companies have been awarded as Sustainability champions by Ecovadis

At Sacco System we have always put Sustainability at the very core of our activities and our commitment, which is why we are proud that our companies Caglificio Clerici…

18 March 2024
News
List Biotherapeutics and Sacco System Announce Lead Share Agreement

List Biotherapeutics, Inc. (List Bio) and Sacco System Australia Pty Ltd (Sacco) today announced a lead share agreement…

26 February 2024
News
CSL FRANCE becomes SACCO SYSTEM FRANCE

Sacco System is the international biotechnological company dedicated to the food, nutraceutical, and pharmaceutical industries…

We are glad to present our latest cultures range for mozzarella for pizza: Margherita.
To help cheesemakers around the world produce the original pizza cheese we have developed MARGHERITA – Italian pizza cheese cultures, a new line of specific lactic acid bacteria for the production of mozzarella for pizza that ensures:

  • extra fermentation speed
  • improved stretchability
  • fine slicing
  • standardization of production time
  • low post acidification
  • excellent browning control.


Contact us at info@saccosystem.com to develop the best solution for your business!

Latest News

19 March 2026
A regulatory achievement for Sacco System: our Heat-Inactivated CRL1505® receives GRAS status

An important regulatory goal has been achieved with the conclusion reached by an independent expert panel for the self-affirmed GRAS (Generally Recognized as Safe) determination of our postbiotic CRL1505® HI.

24 January 2026
SYNBIO®: Sacco System’s probiotic support for healthy ageing

The global population is ageing faster than ever before. In 2019, life expectancy at birth reached 72.8 years almost 9 years more than in 1990. In this context, staying healthy

22 December 2025
Sacco System grows in Latin America: BioInsumos in Uruguay and Sacco Brasil acquired.

The Group is accelerating its South American growth strategy through a twofold transaction: the acquisition of a Uruguayan company and the full absorption of its Brazilian subsidiary. The Group is

11 December 2025
Sacco System Presents PerforMilk®: Unlocking Milk’s Full Potential by Preserving Protein Quality 

Milk is the most precious resource in dairy production. High-quality dairy products start with high-quality milk—and in today’s rapidly evolving dairy landscape, protecting that quality has never been more critical. 

20 November 2025
Unveiling the survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model

“Survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model” is the title of the study that has been

07 February 2025
L. rhamnosus CA15 Achieves GRAS Status: A Milestone for Women’s Health

GRAS (Generally Recognised as Safe) is a designation by the US Food and Drug Administration (FDA) that indicates that a substance is considered safe based on expert consensus or a

08 January 2025
Sacco System Australia’s Heat-Inactivated Postbiotics Receive Positive Recommendations from FSANZ

Brisbane, 8 January 2025 Sacco System Australia, a leader in innovative probiotic and postbiotic solutions, is proud to announce that L. rhamnosus CRL 1505 HI (heat-inactivated) and Lactobacillus acidophilus LA1

25 November 2024
News
Our 2023 sustainability report is online!

We are proud to present the fifth edition of our Sustainability Report, an opportunity to reflect on the milestones achieved and the challenges ahead…

16 April 2024
News
Sacco System is pleased to announce the grand opening of its development site in Australia.

Today in the presence of Luna Angelini Marinucci, from 2022 the Consul of Italy in Brisbane, with territorial jurisdiction over the State of Queensland…

26 March 2024
News
Sacco System companies have been awarded as Sustainability champions by Ecovadis

At Sacco System we have always put Sustainability at the very core of our activities and our commitment, which is why we are proud that our companies Caglificio Clerici…

18 March 2024
News
List Biotherapeutics and Sacco System Announce Lead Share Agreement

List Biotherapeutics, Inc. (List Bio) and Sacco System Australia Pty Ltd (Sacco) today announced a lead share agreement…

26 February 2024
News
CSL FRANCE becomes SACCO SYSTEM FRANCE

Sacco System is the international biotechnological company dedicated to the food, nutraceutical, and pharmaceutical industries…

Farewell to Oreste Pattini.
The memory of a friend, Antonio Cava

Latest News

19 March 2026
A regulatory achievement for Sacco System: our Heat-Inactivated CRL1505® receives GRAS status

An important regulatory goal has been achieved with the conclusion reached by an independent expert panel for the self-affirmed GRAS (Generally Recognized as Safe) determination of our postbiotic CRL1505® HI.

24 January 2026
SYNBIO®: Sacco System’s probiotic support for healthy ageing

The global population is ageing faster than ever before. In 2019, life expectancy at birth reached 72.8 years almost 9 years more than in 1990. In this context, staying healthy

22 December 2025
Sacco System grows in Latin America: BioInsumos in Uruguay and Sacco Brasil acquired.

The Group is accelerating its South American growth strategy through a twofold transaction: the acquisition of a Uruguayan company and the full absorption of its Brazilian subsidiary. The Group is

11 December 2025
Sacco System Presents PerforMilk®: Unlocking Milk’s Full Potential by Preserving Protein Quality 

Milk is the most precious resource in dairy production. High-quality dairy products start with high-quality milk—and in today’s rapidly evolving dairy landscape, protecting that quality has never been more critical. 

20 November 2025
Unveiling the survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model

“Survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model” is the title of the study that has been

07 February 2025
L. rhamnosus CA15 Achieves GRAS Status: A Milestone for Women’s Health

GRAS (Generally Recognised as Safe) is a designation by the US Food and Drug Administration (FDA) that indicates that a substance is considered safe based on expert consensus or a

08 January 2025
Sacco System Australia’s Heat-Inactivated Postbiotics Receive Positive Recommendations from FSANZ

Brisbane, 8 January 2025 Sacco System Australia, a leader in innovative probiotic and postbiotic solutions, is proud to announce that L. rhamnosus CRL 1505 HI (heat-inactivated) and Lactobacillus acidophilus LA1

25 November 2024
News
Our 2023 sustainability report is online!

We are proud to present the fifth edition of our Sustainability Report, an opportunity to reflect on the milestones achieved and the challenges ahead…

16 April 2024
News
Sacco System is pleased to announce the grand opening of its development site in Australia.

Today in the presence of Luna Angelini Marinucci, from 2022 the Consul of Italy in Brisbane, with territorial jurisdiction over the State of Queensland…

26 March 2024
News
Sacco System companies have been awarded as Sustainability champions by Ecovadis

At Sacco System we have always put Sustainability at the very core of our activities and our commitment, which is why we are proud that our companies Caglificio Clerici…

18 March 2024
News
List Biotherapeutics and Sacco System Announce Lead Share Agreement

List Biotherapeutics, Inc. (List Bio) and Sacco System Australia Pty Ltd (Sacco) today announced a lead share agreement…

26 February 2024
News
CSL FRANCE becomes SACCO SYSTEM FRANCE

Sacco System is the international biotechnological company dedicated to the food, nutraceutical, and pharmaceutical industries…

Starting today online our new webinar section with a dense calendar of events where you can virtually meet our experts, discover the innovations of the dairy sector and, receive all the advice to better follow the whole chain, from fodder to cheese!

In our webinars we will deal with topics such as: taking care of cheeses during the ripening process, discovering the secrets of rennet and the different characteristics in its paste, liquid and powder variants or, how to contain unwanted microorganisms in fresh cheeses or how to prepare the serum-graft to consequently improve the balance of the microflora. We will also deal with issues related to the trends and innovations of non-European markets on a journey to discover local products such as dahi and kefir without obviously forgetting the emerging market of dairy-free fermented products.

Latest News

19 March 2026
A regulatory achievement for Sacco System: our Heat-Inactivated CRL1505® receives GRAS status

An important regulatory goal has been achieved with the conclusion reached by an independent expert panel for the self-affirmed GRAS (Generally Recognized as Safe) determination of our postbiotic CRL1505® HI.

24 January 2026
SYNBIO®: Sacco System’s probiotic support for healthy ageing

The global population is ageing faster than ever before. In 2019, life expectancy at birth reached 72.8 years almost 9 years more than in 1990. In this context, staying healthy

22 December 2025
Sacco System grows in Latin America: BioInsumos in Uruguay and Sacco Brasil acquired.

The Group is accelerating its South American growth strategy through a twofold transaction: the acquisition of a Uruguayan company and the full absorption of its Brazilian subsidiary. The Group is

11 December 2025
Sacco System Presents PerforMilk®: Unlocking Milk’s Full Potential by Preserving Protein Quality 

Milk is the most precious resource in dairy production. High-quality dairy products start with high-quality milk—and in today’s rapidly evolving dairy landscape, protecting that quality has never been more critical. 

20 November 2025
Unveiling the survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model

“Survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model” is the title of the study that has been

07 February 2025
L. rhamnosus CA15 Achieves GRAS Status: A Milestone for Women’s Health

GRAS (Generally Recognised as Safe) is a designation by the US Food and Drug Administration (FDA) that indicates that a substance is considered safe based on expert consensus or a

08 January 2025
Sacco System Australia’s Heat-Inactivated Postbiotics Receive Positive Recommendations from FSANZ

Brisbane, 8 January 2025 Sacco System Australia, a leader in innovative probiotic and postbiotic solutions, is proud to announce that L. rhamnosus CRL 1505 HI (heat-inactivated) and Lactobacillus acidophilus LA1

25 November 2024
News
Our 2023 sustainability report is online!

We are proud to present the fifth edition of our Sustainability Report, an opportunity to reflect on the milestones achieved and the challenges ahead…

16 April 2024
News
Sacco System is pleased to announce the grand opening of its development site in Australia.

Today in the presence of Luna Angelini Marinucci, from 2022 the Consul of Italy in Brisbane, with territorial jurisdiction over the State of Queensland…

26 March 2024
News
Sacco System companies have been awarded as Sustainability champions by Ecovadis

At Sacco System we have always put Sustainability at the very core of our activities and our commitment, which is why we are proud that our companies Caglificio Clerici…

18 March 2024
News
List Biotherapeutics and Sacco System Announce Lead Share Agreement

List Biotherapeutics, Inc. (List Bio) and Sacco System Australia Pty Ltd (Sacco) today announced a lead share agreement…

26 February 2024
News
CSL FRANCE becomes SACCO SYSTEM FRANCE

Sacco System is the international biotechnological company dedicated to the food, nutraceutical, and pharmaceutical industries…

We are glad to present our latest cultures range for plant-based fermented products, VChoice.

VChoice is a new dairy-free cultures range, composed of pure and controlled hypoallergenic cultures, free of any known allergen as well as animal-derived products.
The perfect cultures for soy, coconut, oat milk and any other plant-based fermented products, which ensure good fermentation time, texture, flavour and aroma development.

All the products of the VChoice cultures range are dairy-free.

Contact us at info@saccosystem.com to develop the best solution for your desired finished product!

Latest News

19 March 2026
A regulatory achievement for Sacco System: our Heat-Inactivated CRL1505® receives GRAS status

An important regulatory goal has been achieved with the conclusion reached by an independent expert panel for the self-affirmed GRAS (Generally Recognized as Safe) determination of our postbiotic CRL1505® HI.

24 January 2026
SYNBIO®: Sacco System’s probiotic support for healthy ageing

The global population is ageing faster than ever before. In 2019, life expectancy at birth reached 72.8 years almost 9 years more than in 1990. In this context, staying healthy

22 December 2025
Sacco System grows in Latin America: BioInsumos in Uruguay and Sacco Brasil acquired.

The Group is accelerating its South American growth strategy through a twofold transaction: the acquisition of a Uruguayan company and the full absorption of its Brazilian subsidiary. The Group is

11 December 2025
Sacco System Presents PerforMilk®: Unlocking Milk’s Full Potential by Preserving Protein Quality 

Milk is the most precious resource in dairy production. High-quality dairy products start with high-quality milk—and in today’s rapidly evolving dairy landscape, protecting that quality has never been more critical. 

20 November 2025
Unveiling the survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model

“Survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model” is the title of the study that has been

07 February 2025
L. rhamnosus CA15 Achieves GRAS Status: A Milestone for Women’s Health

GRAS (Generally Recognised as Safe) is a designation by the US Food and Drug Administration (FDA) that indicates that a substance is considered safe based on expert consensus or a

08 January 2025
Sacco System Australia’s Heat-Inactivated Postbiotics Receive Positive Recommendations from FSANZ

Brisbane, 8 January 2025 Sacco System Australia, a leader in innovative probiotic and postbiotic solutions, is proud to announce that L. rhamnosus CRL 1505 HI (heat-inactivated) and Lactobacillus acidophilus LA1

25 November 2024
News
Our 2023 sustainability report is online!

We are proud to present the fifth edition of our Sustainability Report, an opportunity to reflect on the milestones achieved and the challenges ahead…

16 April 2024
News
Sacco System is pleased to announce the grand opening of its development site in Australia.

Today in the presence of Luna Angelini Marinucci, from 2022 the Consul of Italy in Brisbane, with territorial jurisdiction over the State of Queensland…

26 March 2024
News
Sacco System companies have been awarded as Sustainability champions by Ecovadis

At Sacco System we have always put Sustainability at the very core of our activities and our commitment, which is why we are proud that our companies Caglificio Clerici…

18 March 2024
News
List Biotherapeutics and Sacco System Announce Lead Share Agreement

List Biotherapeutics, Inc. (List Bio) and Sacco System Australia Pty Ltd (Sacco) today announced a lead share agreement…

26 February 2024
News
CSL FRANCE becomes SACCO SYSTEM FRANCE

Sacco System is the international biotechnological company dedicated to the food, nutraceutical, and pharmaceutical industries…

Probiotics have been shown to effectively reduce the incidence of respiratory tract infections (RTIs). In particular, the strain Lactobacillus rhamnosus CRL1505 has demonstrated an important capacity to keep RTIs at bay.

Clinical evidence

A randomized, double-blind, placebo-controlled trial with 298 pre-school children (2-5 years old) that consumed either yogurt containing CRL1505 (>10E8 cfu/day) or a placebo yogurt 5 days/week for 6 months showed [1]:

Lower use of antibiotics



A significantly reduced number of infections in children consuming the probiotic-containing yogurt. In particular, it lowered the incidence of:

  • upper respiratory tract infection
  • pharyngitis and tonsillitis
  • acute diarrhea

In vivo, preclinical evidence

CRL1505 led to an earlier immune response and reduced lung damage when nasal challenges with different types of virus were performed [2-3].

CRL1505 heightened infection resistance to the airway pathogen Streptococcus pneumoniae serotype 14, mice models. [4-5]

Heat-inactivated CRL1505 when administered intranasally has similar benefits to those observed when the live probiotic is administered [6].

Mechanisms of action

The mechanisms of action of CRL1505 have been unveiled in a series of in vivo models, and include increased basal levels of interferon-gamma (IFN-y) in the host, a key activator of the innate and adaptive immune system, and of the anti-inflammatory cytokine interleukin 10 (IL-10) [4]. These modulations allow the priming of the immune system to tackle RTIs through an overall stimulation of the immune system, intra-and extra-intestinally [4].


1 Villena J, Salva S, Núñez M, Corzo J, Tolaba R, Faedda J, Font G, Alvarez S. (2012). Probiotics for everyone! The novel immunobiotic Lactobacillus rhamnosus CRL1505 and the beginning of social probiotic programs in Argentina. International Journal of Biotechnology for Wellness Industries. 1: 189-198.
2 Chiba E, Tomosada Y, Vizoso-Pinto MG, Salva S, Takahashi T, Tsukida K, Kitazawa H, Alvarez S, Villena J. (2013). Immunobiotic Lactobacillus rhamnosus improves the resistance of infant mice against respiratory syncytial virus infection. International Immunopharmacology 17: 373-382.
3 Zelaya H, Tsukida K, Chiba E, Marranzino G, Alvarez S, Kitazawa H, Agu?ero G, Villena J. (2014). Immunobiotic lactobacilli reduce viral-associated pulmonary damage through the modulation of inflammation–coagulation interactions. International Immunopharmacology 19: 161-173.
4 Salva S, Villena J, Alvarez S. (2010). Immunomodulatory activity of Lactobacillus rhamnosus strains isolated from goat milk: Impact on intestinal and respiratory infections. Int J Food Microbiol 141(1-2): 82-9.
5 Salva S, Núñez M, Villena J, Ramón A, Fonta G, Alvarez S. (2011). Development of a fermented goats’ milk containing Lactobacillus rhamnosus: in vivo study of health benefits. J Sci Food Agric 91: 2355–2362.
6 Tomosada Y, Chiba E, Zelaya H, Takahashi T, Tsukida K, Kitazawa H, Alvarez S, Villena J. (2013). Nasally administered Lactobacillus rhamnosus strains differentially modulate respiratory antiviral immune responses and induce protection against respiratory syncytial virus infection. BMC Immunology, 14: 40.

Latest News

19 March 2026
A regulatory achievement for Sacco System: our Heat-Inactivated CRL1505® receives GRAS status

An important regulatory goal has been achieved with the conclusion reached by an independent expert panel for the self-affirmed GRAS (Generally Recognized as Safe) determination of our postbiotic CRL1505® HI.

24 January 2026
SYNBIO®: Sacco System’s probiotic support for healthy ageing

The global population is ageing faster than ever before. In 2019, life expectancy at birth reached 72.8 years almost 9 years more than in 1990. In this context, staying healthy

22 December 2025
Sacco System grows in Latin America: BioInsumos in Uruguay and Sacco Brasil acquired.

The Group is accelerating its South American growth strategy through a twofold transaction: the acquisition of a Uruguayan company and the full absorption of its Brazilian subsidiary. The Group is

11 December 2025
Sacco System Presents PerforMilk®: Unlocking Milk’s Full Potential by Preserving Protein Quality 

Milk is the most precious resource in dairy production. High-quality dairy products start with high-quality milk—and in today’s rapidly evolving dairy landscape, protecting that quality has never been more critical. 

20 November 2025
Unveiling the survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model

“Survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model” is the title of the study that has been

07 February 2025
L. rhamnosus CA15 Achieves GRAS Status: A Milestone for Women’s Health

GRAS (Generally Recognised as Safe) is a designation by the US Food and Drug Administration (FDA) that indicates that a substance is considered safe based on expert consensus or a

08 January 2025
Sacco System Australia’s Heat-Inactivated Postbiotics Receive Positive Recommendations from FSANZ

Brisbane, 8 January 2025 Sacco System Australia, a leader in innovative probiotic and postbiotic solutions, is proud to announce that L. rhamnosus CRL 1505 HI (heat-inactivated) and Lactobacillus acidophilus LA1

25 November 2024
News
Our 2023 sustainability report is online!

We are proud to present the fifth edition of our Sustainability Report, an opportunity to reflect on the milestones achieved and the challenges ahead…

16 April 2024
News
Sacco System is pleased to announce the grand opening of its development site in Australia.

Today in the presence of Luna Angelini Marinucci, from 2022 the Consul of Italy in Brisbane, with territorial jurisdiction over the State of Queensland…

26 March 2024
News
Sacco System companies have been awarded as Sustainability champions by Ecovadis

At Sacco System we have always put Sustainability at the very core of our activities and our commitment, which is why we are proud that our companies Caglificio Clerici…

18 March 2024
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List Biotherapeutics and Sacco System Announce Lead Share Agreement

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26 February 2024
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CSL FRANCE becomes SACCO SYSTEM FRANCE

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Yogurt comes from a milk’s preservation process, but you never believe the discovering process, happened as a coincidence of a series of events.

The name yogurt is coined by the Turkish verb “Yogurmak” that means “to Thicken” and the first experimenters are the desert travellers upon their camels, during the 6TH century BC.
To bring nutrient milk with them, the Bedouins used containers made by the skin of animal stomachs. During the travel, the milk, mixed with animal’s enzymes present on the containers, and exposed to high desert’s temperatures, got a transformation process, becoming a sour and creamy food with many nutritive values. From a mistake, they discovered one of the most famous and consumed products of the world.

Fundamentally, yogurt is heated and mixed with 2 live bacteria, Lactobacillus bulgaricus and Streptococcus thermophilus, good bacteria that keep our intestines healthy. The flavour is directly influenced by the greater or lesser presence of the lactobacilli in the yogurt: if it is very acid, in general, it means that there are few lactobacilli, if instead, it is sweet it is exactly the opposite.

Market value:

Currently the yogurt market is quite stable in its own growth. The rising level is equilibrated and durable, with a stable and positive forecast until 2025.
Global yogurt sales are raising at CAGR* 4.7% yearly. The last year sales value has overcome the value of € 60 Billion and today as a global value of more than € 70 Billion.

Trend analysis:

Nowadays yogurt became a trend all around the world with an offer of many flavours and packages useful to satisfy every need and every palate. Moreover, yogurt has different declination, from the classic one, through the low fat and probiotic version, to the plant-based for vegan purposes.

The lead driver of the yogurt market is the flavour.

Could you imagine the winners?

Strawberry is the leading flavour followed by vanilla, and the podium is completed by peach as the third-best flavour choice for yogurt’s consumers.
“Tropical Yogurt”, with exotic flavours is the new line rising, with mango as the best flavour consumed.

*Compound Annual Growth Rate

Latest News

19 March 2026
A regulatory achievement for Sacco System: our Heat-Inactivated CRL1505® receives GRAS status

An important regulatory goal has been achieved with the conclusion reached by an independent expert panel for the self-affirmed GRAS (Generally Recognized as Safe) determination of our postbiotic CRL1505® HI.

24 January 2026
SYNBIO®: Sacco System’s probiotic support for healthy ageing

The global population is ageing faster than ever before. In 2019, life expectancy at birth reached 72.8 years almost 9 years more than in 1990. In this context, staying healthy

22 December 2025
Sacco System grows in Latin America: BioInsumos in Uruguay and Sacco Brasil acquired.

The Group is accelerating its South American growth strategy through a twofold transaction: the acquisition of a Uruguayan company and the full absorption of its Brazilian subsidiary. The Group is

11 December 2025
Sacco System Presents PerforMilk®: Unlocking Milk’s Full Potential by Preserving Protein Quality 

Milk is the most precious resource in dairy production. High-quality dairy products start with high-quality milk—and in today’s rapidly evolving dairy landscape, protecting that quality has never been more critical. 

20 November 2025
Unveiling the survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model

“Survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model” is the title of the study that has been

07 February 2025
L. rhamnosus CA15 Achieves GRAS Status: A Milestone for Women’s Health

GRAS (Generally Recognised as Safe) is a designation by the US Food and Drug Administration (FDA) that indicates that a substance is considered safe based on expert consensus or a

08 January 2025
Sacco System Australia’s Heat-Inactivated Postbiotics Receive Positive Recommendations from FSANZ

Brisbane, 8 January 2025 Sacco System Australia, a leader in innovative probiotic and postbiotic solutions, is proud to announce that L. rhamnosus CRL 1505 HI (heat-inactivated) and Lactobacillus acidophilus LA1

25 November 2024
News
Our 2023 sustainability report is online!

We are proud to present the fifth edition of our Sustainability Report, an opportunity to reflect on the milestones achieved and the challenges ahead…

16 April 2024
News
Sacco System is pleased to announce the grand opening of its development site in Australia.

Today in the presence of Luna Angelini Marinucci, from 2022 the Consul of Italy in Brisbane, with territorial jurisdiction over the State of Queensland…

26 March 2024
News
Sacco System companies have been awarded as Sustainability champions by Ecovadis

At Sacco System we have always put Sustainability at the very core of our activities and our commitment, which is why we are proud that our companies Caglificio Clerici…

18 March 2024
News
List Biotherapeutics and Sacco System Announce Lead Share Agreement

List Biotherapeutics, Inc. (List Bio) and Sacco System Australia Pty Ltd (Sacco) today announced a lead share agreement…

26 February 2024
News
CSL FRANCE becomes SACCO SYSTEM FRANCE

Sacco System is the international biotechnological company dedicated to the food, nutraceutical, and pharmaceutical industries…

Centro Sperimentale del Latte is open to partners and new distributors.

The products of our Agro-Vet division are the natural way to improve silage fermentation, intestinal well-being and animal production performance, as well as the quality of livestock products.

Are you a distributor of agro-livestock products and are you looking for safe and quality crops and probiotics?

JOIN US!

Latest News

19 March 2026
A regulatory achievement for Sacco System: our Heat-Inactivated CRL1505® receives GRAS status

An important regulatory goal has been achieved with the conclusion reached by an independent expert panel for the self-affirmed GRAS (Generally Recognized as Safe) determination of our postbiotic CRL1505® HI.

24 January 2026
SYNBIO®: Sacco System’s probiotic support for healthy ageing

The global population is ageing faster than ever before. In 2019, life expectancy at birth reached 72.8 years almost 9 years more than in 1990. In this context, staying healthy

22 December 2025
Sacco System grows in Latin America: BioInsumos in Uruguay and Sacco Brasil acquired.

The Group is accelerating its South American growth strategy through a twofold transaction: the acquisition of a Uruguayan company and the full absorption of its Brazilian subsidiary. The Group is

11 December 2025
Sacco System Presents PerforMilk®: Unlocking Milk’s Full Potential by Preserving Protein Quality 

Milk is the most precious resource in dairy production. High-quality dairy products start with high-quality milk—and in today’s rapidly evolving dairy landscape, protecting that quality has never been more critical. 

20 November 2025
Unveiling the survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model

“Survivability of probiotic CA15 strain with and without fluconazole co-administration and its effect on gut microbiota and metabolome through SHIME® model” is the title of the study that has been

07 February 2025
L. rhamnosus CA15 Achieves GRAS Status: A Milestone for Women’s Health

GRAS (Generally Recognised as Safe) is a designation by the US Food and Drug Administration (FDA) that indicates that a substance is considered safe based on expert consensus or a

08 January 2025
Sacco System Australia’s Heat-Inactivated Postbiotics Receive Positive Recommendations from FSANZ

Brisbane, 8 January 2025 Sacco System Australia, a leader in innovative probiotic and postbiotic solutions, is proud to announce that L. rhamnosus CRL 1505 HI (heat-inactivated) and Lactobacillus acidophilus LA1

25 November 2024
News
Our 2023 sustainability report is online!

We are proud to present the fifth edition of our Sustainability Report, an opportunity to reflect on the milestones achieved and the challenges ahead…

16 April 2024
News
Sacco System is pleased to announce the grand opening of its development site in Australia.

Today in the presence of Luna Angelini Marinucci, from 2022 the Consul of Italy in Brisbane, with territorial jurisdiction over the State of Queensland…

26 March 2024
News
Sacco System companies have been awarded as Sustainability champions by Ecovadis

At Sacco System we have always put Sustainability at the very core of our activities and our commitment, which is why we are proud that our companies Caglificio Clerici…

18 March 2024
News
List Biotherapeutics and Sacco System Announce Lead Share Agreement

List Biotherapeutics, Inc. (List Bio) and Sacco System Australia Pty Ltd (Sacco) today announced a lead share agreement…

26 February 2024
News
CSL FRANCE becomes SACCO SYSTEM FRANCE

Sacco System is the international biotechnological company dedicated to the food, nutraceutical, and pharmaceutical industries…