{"id":12471,"date":"2025-06-17T17:17:39","date_gmt":"2025-06-17T15:17:39","guid":{"rendered":"https:\/\/saccosystem.com\/?p=12471"},"modified":"2025-06-17T17:17:39","modified_gmt":"2025-06-17T15:17:39","slug":"l-rhamnosus-ca15-the-probiotic-allied-to-womens-well-being-2","status":"publish","type":"post","link":"https:\/\/saccosystem.com\/en\/blog\/l-rhamnosus-ca15-the-probiotic-allied-to-womens-well-being-2\/","title":{"rendered":"L. rhamnosus CA15: the probiotic allied to women&#8217;s well-being"},"content":{"rendered":"<div class=\"breadcrumbs style-1\"\">\n            <div class=\"row\">\n            <div class=\"col\">\n                <div class=\"pages\">\n            <span class=\"page parent\"><a href=\"https:\/\/saccosystem.com\/en\/blog-posts\/\">Blog<\/a><span class=\"separator\">&gt;<\/span><\/span><span class=\"page current\">L. rhamnosus CA15: the probiotic allied to women&#8217;s well-being<\/span>                <\/div>\n            <\/div>\n        <\/div>\n    <\/div>\n\n<div class=\"title-style-blog\">\n            <div class=\"row\">\n            <div class=\"col\">\n                <h1>\n                    L. rhamnosus CA15: the probiotic allied to women&#8217;s well-being                <\/h1>\n                <div class=\"blog-tags tags\">\n                                    <\/div>\n                <h2 class=\"date\">\n                    17\/06\/2025                <\/h2>\n            <\/div>\n        <\/div>\n    <\/div>\n\n<figure class=\"wp-block-post-featured-image\"><img loading=\"lazy\" decoding=\"async\" width=\"1000\" height=\"490\" src=\"https:\/\/saccosystem.com\/wp-content\/uploads\/2025\/06\/Strumenti-per-il-monitoraggio-del-latte-Sacco-System-Labware.jpg\" class=\"attachment-post-thumbnail size-post-thumbnail wp-post-image\" alt=\"Strumenti per il monitoraggio del latte: qualit\u00e0, sicurezza e innovazione con Labware by Sacco System\" style=\"object-fit:cover;\" srcset=\"https:\/\/saccosystem.com\/wp-content\/uploads\/2025\/06\/Strumenti-per-il-monitoraggio-del-latte-Sacco-System-Labware.jpg 1000w, https:\/\/saccosystem.com\/wp-content\/uploads\/2025\/06\/Strumenti-per-il-monitoraggio-del-latte-Sacco-System-Labware-300x147.jpg 300w, https:\/\/saccosystem.com\/wp-content\/uploads\/2025\/06\/Strumenti-per-il-monitoraggio-del-latte-Sacco-System-Labware-768x376.jpg 768w\" sizes=\"auto, (max-width: 1000px) 100vw, 1000px\" \/><\/figure>\n\n\n<div class=\"wp-block-group row\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-group col-lg-8\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<p><strong>Lactobacilli<\/strong>&nbsp;play a vital role in maintaining homeostasis in&nbsp;<strong>vaginal microbiota<\/strong>&nbsp;and there have been promising results not only for the treatment of&nbsp;<strong>dysbiosis<\/strong>, but also its&nbsp;<strong>onset<\/strong>&nbsp;in the first place.<\/p>\n\n\n\n<p>A recent clinical trial has shown that, in as few as 10 days, consumption of the&nbsp;<strong>probiotic&nbsp;<\/strong><strong><em><strong><em>L. rhamnosus<\/em><\/strong><\/em><\/strong><strong>&nbsp;CA15<\/strong>&nbsp;by mouth is able to&nbsp;<strong>reduce the severity and lower the extent of vaginal dysbiosis<\/strong>&nbsp;caused by candida overgrowth and bacterial infection.<\/p>\n\n\n\n<p>Even after supplementation of probiotics has finished,&nbsp;<strong>beneficial effects continue for up to 30 days<\/strong>, maintaining&nbsp;<strong>vaginal eubiosis<\/strong>&nbsp;and averting the danger of relapse.<\/p>\n\n\n\n<p>The&nbsp;<strong>CA15 probiotic<\/strong>&nbsp;promotes the&nbsp;<strong>balance of the vaginal microbiota<\/strong>, fostering the development of good bacteria to the detriment of other potentially dangerous microorganisms that could lead to fungal or bacterial vaginitis and vaginosis.<\/p>\n<\/div><\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-group row\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<div style=\"height:48px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-group col-lg-8\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<h2 class=\"wp-block-heading\">The beneficial effects of&nbsp;<em>L. rhamnosus<\/em>&nbsp;CA15<\/h2>\n\n\n\n<div style=\"height:32px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>The clinical and preclinical&nbsp;<strong>findings<\/strong>&nbsp;of this trial point to the ability of the probiotic strain&nbsp;<strong><em><strong><em>L. rhamnosus<\/em><\/strong><\/em><\/strong><strong>&nbsp;CA15 (DSM 33960)<\/strong>, administered by mouth, to&nbsp;<strong>restore homeostasis in the vaginal microbiota<\/strong>&nbsp;and, therefore, to significantly reduce clinical signs and symptoms, improving the quality of life for&nbsp;<strong>women of reproductive age<\/strong>.&nbsp;<\/p>\n\n\n\n<p>More especially, the strain&nbsp;<em>L. rhamnosus<\/em>&nbsp;CA15 has been found to have&nbsp;<strong>interesting probiotic properties<\/strong>&nbsp;in vitro which make it capable of:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>inhibiting a broad spectrum <\/strong>of<strong> <\/strong>fungal and bacterial\u00a0<strong>pathogens<\/strong>\u00a0(<em>Escherichia coli, Candida albicans, Candida glabrata, Candida krusei, Candida parapsilosis, Candida tropicalis, Gardnerella vaginalis, Listeria monocytogenes, Pseudomonas aeruginosa, Pseudomonas monteilii, Staphylococcus aureus, Streptococcus agalactiae<\/em>)<\/li>\n\n\n\n<li><strong>inhibiting the formation of biofilms<\/strong> caused by species belonging to the Candida genus<\/li>\n\n\n\n<li><strong>combating colonisation of the vaginal area by pathogenic bacteria<\/strong>, contributing to the maintenance and re-establishment of homeostasis of the&nbsp;<strong>vaginal microbiota<\/strong><\/li>\n\n\n\n<li><strong>producing large amounts of lactic acid<\/strong> which in turn lowers the vaginal pH<\/li>\n\n\n\n<li><strong>exerting an anti-inflammatory action<\/strong><\/li>\n\n\n\n<li><strong>fighting off free radicals<\/strong> through its\u00a0<strong>antioxidant<\/strong>\u00a0action, thus reducing oxidative stress associated with the onset of various diseases.<\/li>\n<\/ul>\n\n\n\n<div style=\"height:48px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">The study<\/h2>\n\n\n\n<div style=\"height:32px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<\/div><\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-group row\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-group col-lg-8\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<p>A&nbsp;<strong>randomised study with a double-blind control group<\/strong>&nbsp;was conducted in order to check the preclinical findings against&nbsp;<em>in vivo<\/em>&nbsp;results, and the effectiveness of CA15 administered by mouth was measured as a treatment for vaginal dysbiosis.&nbsp;<\/p>\n\n\n\n<p>The study was conducted in keeping with&nbsp;<strong>Good Clinical Practices<\/strong>&nbsp;and in accordance with the policies of the World Medical Association (WMA) on ethical standards for medical research on humans.<\/p>\n\n\n\n<p>The clinical trial showed&nbsp;<strong>a statistically meaningful reduction in the signs and symptoms of vaginal dysbiosis<\/strong>&nbsp;(leukorrhea, a burning sensation, subjective perception of vaginal disorders, the presence of vulvovaginal erythaema\/oedema and burning), as well as a&nbsp;<strong>reduction in the Amsel criteria<\/strong>&nbsp;(presence of clue cells, vaginal discharges, production of unpleasant smells and a vaginal pH greater than 4.5) and in the&nbsp;<strong>Nugent score<\/strong>.<\/p>\n\n\n\n<p>These differences were detectable not only&nbsp;<strong>10 days after<\/strong>&nbsp;the start of treatment, but also&nbsp;<strong>during the washout period<\/strong>&nbsp;(<strong>30 days after<\/strong>&nbsp;the treatment ended). No meaningful variations in the aforementioned signs and symptoms were encountered in the placebo group.<\/p>\n\n\n\n<p>As far as the&nbsp;<strong>composition of the vaginal microbiota<\/strong>&nbsp;was concerned, as expected, all the patients when enlisted in the experiment had a low cell density of lactobacilli and a high number of vaginal pathogens, such as&nbsp;<em>G. vaginalis<\/em>, streptococci, enterococci and&nbsp;<em>Candida spp<\/em>. In other words, their microbial ecosystem was in a state of dysbiosis.&nbsp;<strong>Oral administration of the CA15 strain for 10 days<\/strong>&nbsp;resulted in a statistically meaningful reduction of the&nbsp;<strong>pathogenic microorganisms<\/strong>.<\/p>\n\n\n\n<p>A statistical analysis of the data collected from the&nbsp;<strong>questionnaire about quality of life<\/strong>&nbsp;(WHOQOL-BREF) clearly showed that the patients who were administered CA15 experienced an&nbsp;<strong>improvement in physical health, social relations, sexual relations and<\/strong>&nbsp;in the overall&nbsp;<strong>quality of life<\/strong>. On the other hand, no meaningful variations were observed in the placebo group for any of the areas covered by the questionnaire.<\/p>\n\n\n\n<p>For further information, download the<strong>\u00a0full research paper<\/strong>\u00a0beneath or visit the webpage about\u00a0<a href=\"https:\/\/saccosystem.com\/en\/active-ingredients\/probiotics-for-womens-health\/\"><strong>Sacco System probiotics for women\u2019s health.<\/strong><\/a><\/p>\n\n\n\n<div style=\"height:48px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<\/div><\/div>\n<\/div><\/div>\n\n\n<div class=\"block learn-more no-margin-top\">\n                    <div class=\"row\">\n                <div class=\"col-xxl-6\">\n                                <h2>\n                    Attached resources                <\/h2>\n                                                                                    <div class=\"list\">\n                                                    <div class=\"item\">\n                                        <a href=\"https:\/\/saccosystem.com\/wp-content\/uploads\/2024\/11\/014-CA15_IntregatoreNutrizionale_IN26.pdf\" target=\"_blank\">\n                                            <span class=\"title\">\n                                                <span class=\"icon\">\n                                                <svg width=\"32\" height=\"32\" viewBox=\"0 0 32 32\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><mask id=\"mask0_1261_3192\" style=\"mask-type:alpha\" maskUnits=\"userSpaceOnUse\" x=\"0\" y=\"0\" width=\"32\" height=\"32\"><rect width=\"32\" height=\"32\" fill=\"#D9D9D9\"><\/rect><\/mask><g mask=\"url(#mask0_1261_3192)\"><path d=\"M7.07696 27.3332C6.4034 27.3332 5.83329 27.0998 5.36663 26.6332C4.89996 26.1665 4.66663 25.5964 4.66663 24.9228V7.07684C4.66663 6.40328 4.89996 5.83317 5.36663 5.3665C5.83329 4.89984 6.4034 4.6665 7.07696 4.6665H21.0513L27.3333 10.9485V24.9228C27.3333 25.5964 27.1 26.1665 26.6333 26.6332C26.1666 27.0998 25.5965 27.3332 24.923 27.3332H7.07696ZM7.07696 25.3332H24.923C25.0427 25.3332 25.1411 25.2947 25.218 25.2178C25.2948 25.1409 25.3333 25.0426 25.3333 24.9228V11.9998H20V6.6665H7.07696C6.95718 6.6665 6.85885 6.70495 6.78196 6.78184C6.70507 6.85873 6.66663 6.95706 6.66663 7.07684V24.9228C6.66663 25.0426 6.70507 25.1409 6.78196 25.2178C6.85885 25.2947 6.95718 25.3332 7.07696 25.3332ZM9.66663 21.9998H22.3333V19.9998H9.66663V21.9998ZM9.66663 11.9998H16V9.99984H9.66663V11.9998ZM9.66663 16.9998H22.3333V14.9998H9.66663V16.9998Z\" fill=\"#FAFAFC\"><\/path><\/g><\/svg>                                                <\/span>\n                                                <span class=\"text\">\n                                                                                                            <span class=\"date\">\n                                                            2023                                                        <\/span>\n                                                                                                        <span class=\"description\">\n                                                        L.rhamnosus CA15(DSM 33960)                                                    <\/span>\n                                                <\/span>\n                                            <\/span>\n                                            <span class=\"action\">\n                                                                                                <span class=\"icon\">\n                                                    <svg width=\"24\" height=\"24\" viewBox=\"0 0 24 24\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n                                                        <mask id=\"mask0_1261_3199\" style=\"mask-type:alpha\" maskUnits=\"userSpaceOnUse\" x=\"0\" y=\"0\" width=\"24\" height=\"24\">\n                                                            <rect width=\"24\" height=\"24\" fill=\"#D9D9D9\"><\/rect>\n        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                                                                                 <\/span>\n                                        <\/a>\n                                    <\/div>\n                                            <\/div>\n                                                <\/div>\n                <\/div>\n    <\/div>","protected":false},"excerpt":{"rendered":"<p>Lactobacilli&nbsp;play a vital role in maintaining homeostasis in&nbsp;vaginal microbiota&nbsp;and there have been promising results not only for the treatment of&nbsp;dysbiosis, but also its&nbsp;onset&nbsp;in the first place. A recent clinical trial<\/p>\n","protected":false},"author":6,"featured_media":12477,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[165],"tags":[],"class_list":["post-12471","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog-en"],"acf":[],"_links":{"self":[{"href":"https:\/\/saccosystem.com\/en\/wp-json\/wp\/v2\/posts\/12471","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/saccosystem.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/saccosystem.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/saccosystem.com\/en\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/saccosystem.com\/en\/wp-json\/wp\/v2\/comments?post=12471"}],"version-history":[{"count":0,"href":"https:\/\/saccosystem.com\/en\/wp-json\/wp\/v2\/posts\/12471\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/saccosystem.com\/en\/wp-json\/wp\/v2\/media\/12477"}],"wp:attachment":[{"href":"https:\/\/saccosystem.com\/en\/wp-json\/wp\/v2\/media?parent=12471"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/saccosystem.com\/en\/wp-json\/wp\/v2\/categories?post=12471"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/saccosystem.com\/en\/wp-json\/wp\/v2\/tags?post=12471"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}